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Clonogenic assays of primary AML blasts and compared with normal myeloid progenitors. Finally, we have conducted a pilot clinical trial of ara-C in combination with UCN-01 for the therapy of patients with relapsed AML. Chk1 was phosphorylated in most AML samples obtained prior to treatment. Inhibition of Chk1 and Akt signaling was paralleled by an activation of the JNK pathway during therapy suggesting that targeting the Chk1 and Akt pathway may have therapeutic implications in the treatment of AML. PATIENTS, MATERIALS AND METHODS Materials. The ara-C used for in vitro investigations was purchased from Sigma-Aldrich St, Louis, MO. UCN-01 NSC 638850 ; for use in vitro was kindly provided by the Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, National Cancer Institute Bethesda, MD ; . Aliquots of UCN-01 10 mM in DMSO ; were stored at 20oC and diluted in RPMI immediately prior to each experiment. UCN-01 used in the clinical trial was supplied by the Cancer Therapy and Evaluation Program, NCI. All other chemicals were reagent-grade. Patients and Methods. A pilot clinical trial was designed where ara-C was administered at 1 g for 4 days as a continuous infusion with UCN-01 administered at 45 mg m2 d starting day 2 as a continuous infusion. A detailed analysis of the clinical aspects of this trial will be reported separately. After informed consent was obtained under the aegis of the University of Texas MD Anderson Institutional Review Board-approved protocols, blood samples were collected in heparin-containing vacutainer tubes. Mononuclear cells were isolated on Ficoll-Hypaque gradients as described 41 ; . Two patients received 1.5 g m2 d ara-C followed by UCN-01. [BLEEDING AND THROMBOTIC DISORDERS] Coagulation dis orders Applicants with an inherited coagulation disorder or any history of factor replacement or serious bleeding episodes are considered unfit. a Haemophilia Applicants with Factor VIII deficiency are unfit. The AMS may consider certification for Class 2 if there is no history of significant bleeding episodes. b Von Willebrand's disease Applicants with von Willebrand's disease should be denied certification. Individuals without therapy or without a history of significant bleeding episodes may be considered fit by the AMS. c Deep vein thrombosis A history of deep vein thrombosis requires full investigation for underlying conditions. The individual is considered temporarily unfit. d Pulmonary embolism Applicants with a history of pulmonary embolisation, not associated with chronic deep venous thrombosis, are considered temporarily unfit until a period of at least 6 months after anticoagulant therapy has been discontinued and not less than 1 year after the actual pulmonary embolism. e Recurrent pulmonary emboli. Key-words: Jurassic, radiolaria, skeletal morphology, feeding behavior, prey, eco-system. Living radiolarian research provides us with fundamental data for feeding behavior of radiolarians. Detailed observations of a variety in feeding behavior of laboratory cultured radiolarian specimens make it possible to understand the relationship between skeletal morphology and feeding behavior. This work focuses on the application of living radiolarian research to clarifying feeding behavior of Jurassic radiolarians, leading to reconstruct marine eco-system in the Jurassic oceans.

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