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This thesis combines a series of investigations involving both applied and fundamental aspects of microspore embryogenesis. The main results of the applied part deal with the development and characterization of an efficient shed-microspore culture protocol for the production of doubled haploid plants in Indonesian hot pepper Capsicum annuum L. ; , and its implementation under the local conditions of Indonesia. With regard to the more fundamental part of the thesis, a new microspore embryogenesis system has been developed in Brassica napus cv. Topas, and it is shown for the first time that completely normal embryos can be obtained from microspores in culture, which undergo exactly the same developmental pathway as that of zygotic embryos. These results will have potentially significant impact for practical application as well as for fundamental research on unraveling of early plant embryogenesis. The results of the investigations are briefly discussed in the following sections with special emphasis on their relevance to theoretical and practical applications of microspore embryogenesis and their future prospects.
Would magnify the reduction in calcitriol levels in CKD patients and thus provide an additional viable explanation for calcitriol deficiency in early CKD. Importantly, in this study, the strong inverse association between FGF-23 and calcitriol remained significant after adjusting for 25 OH ; D3 stores, which itself remained an independent predictor of calcitriol levels. The latter provides support for the NKF Kidney Disease Outcomes Quality Initiative guideline to supplement vitamin D in CKD patients with subnormal 25 OH ; D3 levels 41 ; . We acknowledge several limitations of this study. First, the cross-sectional design limited our ability to examine longitudinal changes in FGF-23, calcitriol, PTH, and mineral levels in individual patients over time as renal disease progressed; thus, we cannot infer causality or the direction of the associations that we identified. However, we have attempted to limit our interpretation of the data and the potential directions of associations within the context of the published literature regarding the relevant renal and mineral physiology along with emerging data about FGF-23. A second limitation is that we were unable to instruct any of the patients to fast before collecting serum or urine samples; thus, instead of being able to calculate the TmPi GFR, we were forced to examine FePO4 as the measure of renal phosphate handling. This limitation introduced the possibility that dietary variability influenced the results. However, the effect of not standardizing intake would be to bias our results toward the null hypothesis of observing no associations when they truly exist. That we nonetheless observed significant results for each of the hypotheses tested despite the lack of standardization further bolsters our results. Third, the assay that we used to measure FGF-23 levels detects both the intact, biologically active molecule and the inactive C-peptide fragments, which may accumulate as renal function declines. Although accumulation of inactive fragments may have increased in advanced CKD, these assays have been used in previously published studies of CKD patients 17 ; . Furthermore, imprecision in assays would be expected to increase variability and thus bias the results toward the null hypothesis rather than toward the significant findings that we observed. Finally, a primary aim of this study was to test the hypothesis that the phosphaturic effects of FGF-23 are independent of PTH in an in vivo human model of CKD. This aim was examined using statistical techniques, which provided significant results. Nonetheless, it would be preferable in the future to test this hypothesis in longitudinal studies and perhaps in a human parathyroidectomy model, such as CKD patients who are treated with cinacalcet, when potential confounding by PTH could be minimized further. The primary abnormality that triggers the development of SHPT in CKD remains elusive. Some authors have attributed it to the release of PTH from feedback inhibition by falling calcitriol levels because PTH levels begin to rise and calcitriol levels fall long before the emergence of hyperphosphatemia and hypocalcemia 4, 6 ; . Our data support this hypothesis. Furthermore, we propose that increased FGF-23 and, to a lesser extent, 25 OH ; D3 deficiency, when present, are the primary mechanisms of calcitriol deficiency in CKD. This hypothesis has potentially important therapeutic implications. Hyperphos.
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The results are presented as the mean sem. Statistical significance between two unpaired groups was determined by the Mann-Whitney test. To measure the strength of association between the pairs of variables, without specifying dependencies, Spearman order correlations were run. P 0.05 was considered significant for all tests
Some baseline characteristics differed between younger and older patients. First, there was a negative correlation between age and leukocyte count. Median leukocyte count was 21.109 L range, 0.6 to 626 ; in the 88 patients aged less than 45 years as compared to 10.109 L range, 0.5 to 500 ; in the 66 patients aged 45 years or more P 0.045, by the Mann-Whitney test ; . Secondly, the proportion of patients with M-bcr ALL increased with age 25% of patients aged less than 45 years versus 41% of patients aged 45 years or more; P 0.045, by the Fisher's exact test ; . Finally, a duplication of the Philadelphia chromosome was more frequently observed in older patients 9% in patients aged less than 45 years versus 27% in patients aged 45 years or more; P 0.01, by the Fisher's exact test.
Our research is supported by Channel Islands National Park, the Marine Conservation Biology Institute MCBI ; , and the University of Oregon. We thank Ann Huston, Kelly Minas, Bob DeLong NMFS ; , and Ian Williams for their time and support.
Cooked with onion, tomato and capsicum served in a sizzling wok CHICKEN KARAHI CHICKEN TIKKA KARAHI LAMB KARAHI KEEMA KARAHI PRAWN KARAHI MIXED VEGETABLES KING PRAWN KARAHI 7.95 8.95 7.95 and carbachol.
Propofol is currently not authorised for sedation in paediatric ICU patients in Ireland and should not be used for this purpose. Itraconazole Sporanox ; Itraconazole is a triazole antifungal agent, possessing a broad spectrum of activity. It is active against most of the pathogenic dermatophytes and yeast, but also against several pathogenic moulds and other fungi including aspergillus spp, major pathogens in immunocompromised patients. Recent studies conducted in dogs and healthy human volunteers identified negative inotropic effects with the intravenous formulation of itraconazole. In these studies, once the drug was stopped the negative inotropic effects resolved. A mechanism for these cardiac effects has not been determined. Since becoming aware of these findings a review of worldwide spontaneous and postmarketing adverse drug reaction ADR ; reports identified cases of congestive heart failure associated with itraconazole use. In some cases the causal relationship was unclear, because of confounding factors, including some cases of serious underlying conditions. However, a number of reports were identified in patients treated with itraconazole for onychomycosis. While the evidence for a clinically significant inotropic effect of oral itraconazole is not as strong, a small negative inotropic effect of itraconazole might cause cardiac decompensation in "at risk" patients. The product information has been updated to reflect this information and to include additional warnings in the special warnings and special precautions for use, interactions and undesirable effects sections of the documents. Reference: Lancet 2001: 357: 1766-1767 Clopidogrel Plavix.
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PRODUCT TESTED The product utilized for test purposes was as follows: "Cap-Stun" spray; Standard Duty Size Cannister 5% Oleoresin Capsicum Isopropanol Carrier Agent Cap-Stun is a registered trademark of Zarc International ; The committee cannot endorse " Cap-Stun " or any other Oleoresin Capsicum product presently on the market. This product was selected simply because it was the most safely tested and readily available product on the market at the time. The cannisters utilized are now in fact obsolete and have been replaced by ones which have a trigger mechanism, 5.5% Oleoresin Capsicum solutions and increased effective range. Further comments are made regarding commercial products later in this report and carbenicillin.
Is Phytophthora nicotianae iar. parasitica sensu Stamps and al. 1990 ; . Presently, our research on this host-parasite system is going on. Verficillium dahliae, the causal agent of an important disease in the Mediterranean area, is not a major parasite in the tunisian pepper fields. We have only detected sporadic attacks at 'Cap Bon' and 'Bizerte'. Nevertheless, this parasite is not frequent, but we find that most the plants are affected if a plot is infected. A detailed analysis of factors that avoid the development of this disease should be of interest. Botrytis and Sclerotinia cause important diseases when greenhouse growing is combined with high relative humidity. Vims Diseases Main viral agents identified in tunisian pepper crop are : potato virus Y PVY ; , tobacco mosaic virus TMV ; , cucumber mosaic virus CMV ; Mehani, 1975, Cherif and Spire, 1983 ; , alfalfa mosaic virus A.MV ; and tomato bushy stunt virus TBSV ; Cherif and Spire, 1983 ; and potato virus X PV * X ; Cherif, personal communication ; . From all these viruses only PVY and TMV are highly spread with important economical incidence. TMV has been isolated from most areas for greenhouse pepper growing. Jemmali 1987 ; has distinguished at least four biotypes. Some F I hybrids are presently being tested for TMV resistance. Now PVY is considered the most threatening viral agent, particularly when associated either with TMV or CMV Mehani, 1975 ; . According to khadmaoui 199 1 ; pathotypes PVY-0 and PVY- I should be present in pepper fields. A breeding program to transfer the PVY resistance genes from 'CM334' 'Serrano Criollo de Morelos 334' ; to the cultivated varieties is presently in course at INRAT. Besides the above mentioned problems, aphids and mites bring also important difficulties when insecticides are not properly used. Presently, the evolution of these insects to chemical resistant races is a threat. Acknowledgment : The author wish to express his sincere thanks to Dr. R. Gil Ortega for english translation of this article. REFERENCES Allagui M.B., 1993. Evaluation of pepper genotypes to Leveillula taurica Lev. Am. ; resistance in Tunisia. Capsicum and Eggplant Newsletter, 12: 81-82. Cherif C. et Spire D., 1983. Identification du virus de rabougrissement buissonneux de la tomate Tomato Bushy Stunt Virus ; en Tunisie sur toniate, piment et aubergine: Quelques caracte'nistiques de la souche tunisienne. Agronoinie, 3 7 ; : 701- 706. F. A 0., 199 1. Yearbook of trade. Rome F.A.0., 1992. Yearbook of production. Rome.
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L U i Held For Jury. , W a l 30, a n d J SB, of K e y night to operating u alpplase w i t field In , 000 b a l tfte g r a Weeks ago the youths, each with s t o flying i n s took a plana owned by William and T h e -while t h e o watching' knother plane being repaired. T h e landed safely after a flight of "40 m i n press charges, M a n a Oirl W e d Mia, C a l l Busi n e s "where t h e will i n a Birthday, F r a n died W e d hlfl 37th MrtMay, He was jtrlckiB with a h e attack a w e previous a n d had .been confined to his h o m SOft of D r IjOng S r a dentist. I n addition to hli parents h o . survived by a widow a n d one daughter * Revived Aftar Two Hours, Mefflberi of t h first, a i d s two * h o u fluaday i n a effort to r e Kunrlefc of P e Was r e s SUrf off a n u toy J a c lifeguard from a nearby beach. B u r fight t o r BiaB, t w o t Fatally Shot, T h e b Lierey Kelly, L o n g OeeanpOrt a v e early Monday m o r bullet w o u over t h e police s a y self-inflicted, A , SS c a Say b e t Kelly, w h o survive. B a b lit T a b , three-yas, r * oId d a u anBB of M i few d a y fell I n t water, She w a s removed to Man m o u Memorial hospital. T h e child w a s door while her m o t asaaller child. Freehold Man FMrnoted ' D a v been--employed-at-the Endlcatti-Johft ' s o n piafii t w o prom o t e BHII be s u "store at Manasquan, F i v e Bervieaa, F i v e Ily a t t services a t t church, Sunday. They w e r Mrs, M a r r saw h e r Kisk, baptised. Other minahers * are Mrs, W . W , Heap, Donald F . B Mrs, Stephen Risk, ."""' M a y Bpafford W . S for t h e will o p p Ee-eleetionT- M r . g Hospital A n d T3F of F r file's * M o n in" M O B Metflorlai. hcspltali w h e confined two days, H e w a employee * ' i n sfiter, MUs Angela Francis, with w h o lived ' .V".- , K e p t Girl W e d Miss ' D o mmond, * daughtiif ef . M Luelle, E n j m &fl Ltfluis B , P a IlL, w e r e Baarrled 'Surfday a t t Itoaife.--"he--couple wlii-lK'e--ttt Can tori, w h e r has- b e e n ems p l d for s e v MS! ler Auto Body company'. H o u Left t o C 10, b e q u Asb u r y Methodist c h u for a d a "Mildred S t a Children's Heme." Long ftraneh Man W i l 89, of Long B r a his h o m born 1B Sweden and carboplatin.
Deviations are considered "small, " differences of 0.5 to 0.79 standard deviations are considered "moderate, " and differences greater than 0.8 standard deviations are considered "large." Because our normed scores all have a mean of 50 and a standard deviation of 10, this means that differences in mean SF-36 scores of 2 to 4.9 points are interpreted as "small, " 5 to 7.9 points as "moderate, " and 8 or more points as "large." Figures 10-1 and 10-2 show bar graphs of the PCS and MCS scores by analysis group and participation status. Most of the differences in the PCS scores were considered small, around 2 points, with a smaller difference of less than 1 point in group C. For MCS scores, groups A and C showed small, 2-point differences, while the group B and D differences were moderate. The next step was to examine the data for the SF-36 subscales, shown in Table 10-3. Overall, there were no striking differences in the SF-36 subscales. Group A showed small but consistent differences in all the SF-36 subscales, while group B differences were moderate in size, ranging up to 5 points; in all subscales, participants showed smaller values than controls. Group D differences were similar, but slightly smaller, than those of group B. Virtually all the SF-36 subscale differences in groups A, B, and D were statistically significant. In contrast, group C differences were relatively small, and none of them were statistically significant. SF-36 Summary Scales by Potential Confounding Variables Table 10-4 shows adjusted mean SF-36 summary scale values by analysis group for various potential confounding factors, with branch included only for group B, where there were sufficient numbers of Marines. Age was significantly associated with PCS and MCS scores in the majority of analysis groups, while race differences.
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Clusters. Cluster I is the largest cluster consisting of twenty samples. There are two sub-clusters within this cluster showing great resemblance among some samples at 100% similarity level. Cluster II showed relationships between 2 samples 17 and 20 ; . They are similar at 90% similarity level. There were thirteen samples in cluster III; eight of them cannot be distinguished as they show some genetic resemblance within themselves. In cluster IV, samples 13 and 14 were grouped together in this cluster at about 90% similarity level. The linear relationships among the forty Capsicum accessions are shown in the principal component analysis PCA, Figure 2 ; . All accessions separated into two groups; the major one consisting of thirty-nine samples and the other minor group having only one sample 32 ; . The PCA and dendrogram results showed that sample 32 is distinct; this is an indication that it has peculiar traits different from others. Generally, many samples were genetically similar and needs further studies to confirm their genetic diversity and carmustine.
D is the equivalent flow diameter of the jacket or the inner diameter of the coil. V is the fluid coolant ; velocity. The Prandtl number, Pr, is given below and contains heat capacity cp ; , viscosity and thermal conductivity of the fluid.
Layer hummus, tomato and tabouli with capsicum on flatbread lavash works well ; and roll up and carteolol.
The question used to be simply "Which is better, butter or margarine?" We would respond with something like, "we recommend soft-tub margarine with a liquid vegetable oil as the first fat ingredient." But the margarine market has expanded and now includes confusing labels like "zero trans fats", "37% light spread", "squeeze spread with olive oil", and "spreadable butter with canola oil", to name a few. We've got margarines made with plant sterols, margarine spreads made with yogurt, lactose-free margarines, squeezable margarines, spreadable margarines and everything in between. No wonder you're confused.
Word is sometimes described as the Feature List that Ate Cleveland. Dozens or hundreds of features lie untapped by the vast majority of its owners. But here's a buried feature that's well worth noticing: It's the Format pop-up button at the bottom of the Find dialog box, which lets you search for text according to its formatting alone, or in combination with words typed in the "Find what" box ; . By opening this Format menu or pressing c-O ; , you'll see that Word lets you search for: Font. Finds occurrences of, say, Times or Palatino, as well as font characteristics like bold, italic, blue, 12-point, double-underline, shadow, and so on--in any combination. Paragraph. Locates paragraphs according to their indentation, line spacing, leading, outline level, page breaks, and so on. Tabs. Searches for tab stops by position and type. Language. Searches for text you've designated as being in a certain language by highlighting the text and then choosing ToolsLanguage ; . Frame. Locates any frame page 162 ; , according to any of its attributes. Style. Lets you search for, or replace, any of your document's styles see page 141 and caverject.
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The median survival in the entire series n 45 ; was seven months 95% Brookmayer-Crowley confidence interval: 6-9 months ; . Twenty-seven percent of the patients were alive twelve months after starting chemotherapy Figure la ; . Median survival of the 33 patients treated with the fortnightly schedule was 8 months 95% CI: 5-9 months ; , one-year survival rate 24%, and median time to progression 4 months range 1-16 months ; . There was no difference in survival between the patients treated by the weekly VNR-GEM schedule and those treated on the fortnightly schedule P - 0.82, Figure lb ; . Toxicity All 45 patients were evaluable for toxicity, which was assessed in a total of 145 cycles; 20 cycles in the pilot study and 125 cycles in the phase II study. Haematological toxicity is summarised in Table 3. The median number of 28-day cycles per patient in the phase II study was three, ranging from zero to eight cycles. Nine of twelve patients 75% ; suffered grade 3-4 neutropenia in the pilot study. There was one toxic death, attributed to neutropenic fever and sepsis, and two cases of pulmonary embolism. One patient suffered grade 4 thrombocytopenia. The change in schedule resulted in a marked reduction in the rate of neutropenia. Only eight patients 24% ; on the fortnightly schedule suffered grade 3-4 neutropenia P 0.0041 Fisher's exact test ; , resulting in dose reductions or delays for three of them 9% ; . Grade 3-4 neutropenic fever occurred in one patient 3% ; and asthenia in three patients 9% ; . No patient on the fortnightly schedule suffered thrombocytopenia or anaemia and capsicum.
Phosphate translocators in sweet-pepper Capsicum annuum L. ; fruit chromoplasts. Biochemical Journal 320, 710. Schunemann D, Schott K, Borchert S, Heldt W. 1996. Evidence for the expression of the triosephosphate translocator gene in green and non-green tissues of tomato and potato. Plant Molecular Biology 31, 10111. Soll J, Schultz G, Joyard J, Douce R, Block MA. 1985. Localization and synthesis of prenylquinones in isolated outer and inner envelope membranes from spinach chloroplasts. Archives of Biochemistry and Biophysics 238, 2909 and cefazolin.
48 ; the active, pungent principle of capsicum can be an irritant to the eyes and to tender skin, producing a strong burning sensation
As with the other Medicare fee-for-service payment systems that are experiencing rapid spending growth, brisk growth in the intensity and utilization of services is the major reason for the current rates of growth in the OPPS, rather than general price or enrollment changes. Table 6 below illustrates the increases in the volume and intensity of hospital outpatient services over the past several years and cefprozil.
ONYX PHARMACEUTICALS RICHMOND, CA ; Onyx is developing novel adenoviral vectors for treatment of head and neck cancer. This group has developed a mutant virus referred to as ONYX-015 ; that preferentially replicates in tumor and carbachol.
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