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Five years after a tumultuous merger that brought the agency to life, Weber Shandwick outfought fierce competition to take the Network of the Year honour, thanks to a memorable performance that emphasised the agency's ability to lead in a diversity of client sectors. On the new business front, Weber Shandwick had a blockbuster year across the region, with new accounts from British Telecom, Carlson Group, Computer Associates, GE Money, Microsoft MED, Porsche, Procter & Gamble, Taubman Asia, Temasek Holdings and Wyeth Nutrition. The bulk of the new business depended heavily on the network's ability to manage clients in multiple offices -- reflecting the key improvement made by regional chief Andrew Pirie in recent years. While individual offices -- such as Hong Kong -- have shone, the past 12 months witnessed the agency's shift into a truly cohesive regional presence, with excellent performances recorded in Beijing, Shanghai, Singapore and Taiwan. The network spent much of the last 12 months focusing on improving its delivery to multi-market clients. Revenues from large regional clients expanded, with the network now counting 14 clients that generate over a quarter of a million US dollars in revenue, up from eight in 2005. What stood the agency apart was Weber Shandwick's strong results for clients in a diverse range of sectors. Its healthcare practice has become the region's strongest under the leadership of Jill Mortensen, while traditionally strong areas such as technology, corporate and consumer continue to shine. In China, the agency stepped up investment in public affairs and healthcare to complement its marketing and technology savvy. Its corporate practice continues to see strong leadership in Singapore and Hong Kong, while Taiwan's consumer capabilities have won numerous awards -- including this year's Campaign of the Year accolade for President Pharmaceutical Corporation. In terms of talent, the network invested in an exchange programme and leadership awards to nurture young staff. The commitment was solidified with the appointment of a regional learning and development director earlier this year.
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Phenytoin Like levetiracetam, phenytoin is an anticonvulsant drug that has exhibited antimanic effects in case series or smaller, controlled trials. Although phenytoin was first used in the 1940s for the treatment of epilepsy, it was largely forgotten for the treatment of bipolar disorder until recently. Mishory et al.47 enrolled 39 patients with mania bipolar or schizoaffective ; into a 5-week, double-blind study of haloperidol plus phenytoin versus haloperidol plus placebo. Of these, 30 completed 3 weeks of treatment and 25 completed 5 weeks. Results showed that phenytoin add-on was more effective than placebo add-on in treating manic symptoms. The efficacy of phenytoin in prophylaxis of bipolar disorder was examined in a recent double-blind add-on study.54 Bipolar patients who had at least 1 episode per year in the previous 2 years with current maintenance therapy and had been stable for about 4 months were randomly assigned to phenytoin or placebo add-on in a double-blind crossover study with each treatment phase lasting for 6 months. There were a total of 30 observation periods for 23 patients. Relapse rates were significantly greater with placebo N 9 ; compared with phenytoin N 3 ; . These pilot data suggest that phenytoin add-on may have utility in the treatment of acute mania and in mainte.
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This results in ecosystem degradation bush fires; deforestation and soil erosion ; . Various Non-Governmental Organisations NGOs ; operating within the ecosystem are.
| Concerta urinalysisWhich have been undertaken by the World Bank to analyze the current crisis and to identify strategies to reverse the present trends. In the past, Radio and Television programmes have covered the World Water Day events just as a news item but the actual message and information have not come out clearly and effectively so far. The issues regarding water resources management have therefore taken a low profile in national rating. There is a need to lift this profile to get some attention. This can be done through a tool of communication, the proposed National Water Campaign. ASAL areas Drought is a recurrent phenomenon that affects large areas and numbers of people in the country. The cumulative effects of these droughts include the erosion of assets, decreasing ability to cope with future droughts, impoverishment of rural communities and depletion of the Government resources. It is therefore a priority of the Government to strengthen suitable drought preparedness, mitigation, response structures and activities. The effects of drought have become more pronounced in recent decades: in the 1990s there were three major droughts. The effect of the 1991 92 drought in the arid districts led to livestock losses of up to 70% of herds, and unprecedented high rates of child malnutrition of up to 50%. During this drought 1.5 million people in seventeen arid and semi-arid districts of four provinces received relief food assistance. Rains failed again at the end of 1995 up to 1996, leading to another drought situation, which affected an estimated 1.41 million people. The worst drought emergency in recent years affected Central, Eastern, Rift Valley, Coast and North Eastern Provinces, with 4.4 million people requiring food assistance in the year 2000. One cause of drought and desertification is.
Reassuring that the company had been audited and that it continued to hold the ISO 14001 certification. Another page provides two additional short paragraphs describing its forestry activities. One explanation for the poor quality of this report could be that the company has received little guidance on what consists a good report. Alternatively, the company perhaps has had little incentive either negative or positive to provide quality information on its environmental activities. The other report is from multinational subsidiary. The report is available online and it provides only two case studies in its environmental section. No company-wide information was provided. Most of the remainder of the report describes the company's products and services. The report did not provide any financial data either. The company's corporate website, on the other hand, provides a large amount of financial and environmental data from its international operations, none of which is provided in Portuguese. By looking at this report, one can infer that there might be large discrepancies in the quality of reports coming from a corporate source or a national subsidiary. Again, the company perhaps received little guidance on what consists a good reporting practice or it has had little incentive positive or negative ; to provide information on its environmental activities to all stakeholders in all countries in which it operates. Benchmarking Brazilian reports with the GRI guidelines In order to better understand the quality of the reports from Brazilian Charter supporters, their reports where compared to the Global Reporting Initiative GRI ; sustainability and copaxone.
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| Objectives: To explore the antibiotic prescribing pattern for cystitis and the patient-related variables associated with prescription during a 4 year period among Italian general practitioners GPs ; . Methods: We obtained information from the `Health Search Database' HSD ; , an Italian general practice research database. From a total sample of 457 672 eligible patients aged 16 years registered up to December 2002, we included those whose diagnoses could be classified as acute uncomplicated and complicated ; and recurrent cystitis. Patients' features and prevalence of antibiotic users were assessed. Results: Of 35 129 cases diagnosed during the period 19992002, 96.0% of them were acute cystitis 39.2% recorded as uncomplicated ; . The prevalence of cases with acute complicated and uncomplicated cystitis slightly increased during the 4 year period, whereas it remained stable for recurrent cystitis. Most of the cystitis cases reported no diagnostic tests. More than 70% of patients were prescribed with at least one antibiotic, with a 4-fold increased risk of antibiotic use for acute cystitis throughout the study period. The prevalence of antibiotic users reached 86.2% for both acute uncomplicated and complicated cystitis in 2002, and 81.5% for recurrent cystitis. Fluoroquinolones represented the most common antibiotics being prescribed although they markedly decreased during these years. Fosfomycin trometamol use increased dramatically, becoming the first choice for any type of cystitis. Conclusions: Data indicate an evident rise in antibiotic use mostly related to fosfomycin trometamol. They also indicate that such a prescriptive trend finds confirmation from the available evidence for acute uncomplicated cystitis, although the management of recurrent cystitis could be further improved. Keywords: urinary tract infections, general practice, prescribing practice and copegus.
Approximately 30 subjects will be enrolled in this 38 day, open-label study. Subjects cannot have been treated with any methylphenidate or amphetamine containing medication within 4 weeks of the screening visit. Once deemed eligible, subjects will be started on 18 mg of CONCERTA daily for 3 days and titrated up on Day 4 to 36 mg daily for 7 days. Depending on response, tolerability and clinician's discretion, the dose of CONCERTA can continue to be titrated up, every 7 days thereafter, first to 54 mg and then to a MAXIMUM of 72 mg 2 x 36 mg tablets ; per day, in order to achieve the optimal dose for each subject.
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Conclusions: In this study, infection by HCV genotype 4 was predominantly related with intravenous drug use. Infection by subtypes c and d was frequent. Infection was acquired in Africa in 13, 0%. Moreover, the historical relationships between Portugal and several African countries may contribute to the increasing prevalence of genotype 4. The majority of patients were co-infected with HIV and creatine.
Post-retirement healthcare under US GAAP The post-retirement healthcare costs of the UK, US and major overseas post-retirement healthcare schemes have been restated in the following tables in accordance with US GAAP. Minor healthcare plans with costs in 2006 of 8 million 2005 5 million; 2004 nil ; have not been recalculated and have been excluded. Net healthcare cost Service cost Interest cost Amortisation of prior service cost Amortisation of net actuarial loss Net healthcare cost The major assumptions used in calculating the net healthcare cost were: Rate of future healthcare inflation Discount rate Change in benefit obligation Benefit obligation at 1st January Amendments Service cost Interest cost Plan participants' contributions Actuarial gain ; loss Benefits paid Exchange Benefit obligation at 31st December Change in plan assets Fair value of plan assets at 1st January Employer and plan participants' contributions Benefits paid Fair value of plan assets at 31st December 53 ; 43.
Waclawik et al., 1993; Westwood et al., 2005 ; , we found no evidence of degeneration of Type I fiber-predominant soleus from CVA-dosed rats. Interestingly, we found similar concentrations of CVA in both degenerated Type II fiber-predominant EDL and in nondegenerated, Type I fiber-abundant soleus muscle. Evidently, this type of muscle fiber is insensitive to CVA- induced damage. Conflicting data exist as to whether or not exercise exacerbates statin- induced skeletal muscle toxicity Reust et al., 1991; Thompson et al., 1991; Thompson et al., 1997 ; . We found that although serum CK levels at 1 mg kg were significantly greater than controls, they were not further elevated by exercise. However, CK should not be the only parameter to assess muscle degeneration; our data indicate that exercise did exacerbate the incidence and severity of CVAinduced myofiber damage, evident by light microscopy and TEM. Furthermore, muscle symptoms are seen in statin patients lacking elevated CK Phillips et al., 2002 ; . Advanced lesions showing increased inflammatory cell infiltrate in the exercised, high dose group are suggestive of partial regeneration. Exercise may have sensitized the muscle to injury, allowing it to occur earlier than in the nonexercised counterparts. In the present study, 2 weeks of treadmill exercise aggravated the minimal to mild damage produced at 1 mg kg in all muscles except soleus, and increased the susceptibility of gastrocnemius, psoas and EDL muscles to damage, but had no effect on muscle at 0.1 and 0.5 mg kg. We conclude that treadmill exercise exacerbates CVA- induced muscle toxicity. At 0.5 mg kg the only subcellular alterations observed in the present study in nondegenerated fast-twitch EDL by TEM were distended mitochondria with disrupted cristae and cleared matrices. Our results are consistent with recent reports demonstrating statin effects on mitochondria as a potential early event in myotoxicity Bergman et al., 2003; Gambelli et al and crixivan.
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Object. Involuntary movement is an uncommon manifestation of a transient ischemic attack. It may be induced by cerebral hemodynamic insufficiency, which is associated with several cerebral ischemic diseases. The authors present three cases of limb shaking due to moyamoya disease MMD ; or radiation-induced middle cerebral artery stenosis, and three additional cases of choreic movement due to MMD. Neuroimaging studies and surgical outcomes in these patients were retrospectively analyzed to investigate the pathological mechanism underlying the symptoms and to provide guidance for the management of involuntary movement disorders in cases of ischemic cerebral disease. Methods. The patient population included two children and four adults with ages at presentation ranging between 7 and 50 years. The initial presenting symptoms were involuntary movements in all six cases. A magnetic resonance imaging finding common in all cases was a small infarct in the frontal corona radiata, which did not extend to the cortex or basal ganglia. A perfusion defect in the frontoparietal cortical and subcortical regions was demonstrated by singlephoton emission computerized tomography in all patients. Improved hemodynamic circulation in the frontoparietal cortical and subcortical regions occurred in parallel with clinical improvement following indirect or direct bypass surgery. Conclusions. Ischemic dysfunction of the frontal cortical and subcortical motor pathways rather than that of the basal ganglia was suspected to be the cause of the observed contralateral involuntary movements. Direct and indirect bypass surgery can be used effectively to treat involuntary movements in patients with cerebral ischemic diseases such as MMD and in those with stenosis of an intracranial major artery and concerta.
Equasym XL continued The range of capsule strengths available 10mg, 20mg, and 30mg ; allows more flexible dosing with Equasym XL compared to Concerta XL which is currently available as 18mg and 36mg tablets. Locally, Equasym XL may be considered as an alternative to Concerta XL in patients demonstrating evidence of compliance problems * with midday dosing of immediate release methylphenidate, but who do not require therapy in the evening. Treatment should be under the direction of a specialist in childhood behaviour disorders and cubicin.
Hospital-Based Emergency Care: At the Breaking Point." This report encourages hospitals to apply tools to improve the flow of patients through emergency departments, especially through the use of observation units clinical decision units ; . The IOM report also recommends that separate OPPS payment should be made for all conditions for which observation is indicated. We appreciate the continued work and dedication of the Observation and Visit Subcommittee and the APC Panel, along with the findings and recommendations of the IOM. However, in light of the broader CY 2008 OPPS proposal to move toward expanded packaging of payment for supportive, dependent HOPD services, we are not accepting the Panel's recommendation related to adding syncope and dehydration to the list of diagnoses eligible for separate payment or to consider other clinical conditions for separate payment for observation care. We are proposing to package all observation services reported with HCPCS code G0378 ; as part of the proposed changes to packaged services discussed previously in section II.A.4. of this proposed rule. Because we are proposing to package payment for all observation services, we are not proposing to adopt the Panel's recommendation to study claims data for separately payable observation care including claims for observation for syncope and dehydration ; that also include specific minor or routine procedures that have "T" status indicators. We agree with the APC Panel and the IOM that there is currently no compelling rationale for a different OPPS payment approach for observation care for only three specific clinical conditions. We recognize that observation care may play an important role in the treatment of many.
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