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Biotech, Inc.; John Oster Family Foundation; Jane and Lloyd Pettit Foundation; Pfizer, Inc.; Pharmacia and Upjohn; Principal Life Insurance Company; Protide Pharmaceuticals; RGK Foundation; Rhne-Poulenc Rorer Pharmaceuticals, Inc.; Roche Laboratories; SangStat Medical Corporation; Schering AG; Schering-Plough Oncology; Searle; SmithKline Beecham Pharmaceutical; Stackner Family Foundation; The Starr Foundation; StemCell Technologies; SyStemix; Therakos; TheraTechnologies; United Resource Networks; US Oncology; and WyethAyerst Laboratories.
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No contract will be signed for the giant 0 million oil pipeline extension from Kenya to Uganda until a petition filed by Petronet EA Consortium is finalised. A notification from Kenya's Public Procurement Complaints, Review and Appeals Board dated May 17, has declared the completion of the tender process suspended until the petition is heard on June 12, 2006. It was addressed to Kenya's Permanent Secretary in the Ministry of Energy, who along with his Ugandan counterpart chairs the Joint Co-ordinating Commission on Pipeline Extension. "Under the Exchequer and Audit Public Procurement ; Regulations 2001, no contract may be signed between the procuring entity and the tenderers awarded the contract unless the Appeals have been finalised, " it said. A similar appeal was expected to have been filed with Uganda's Public Procurement and Disposal Assets Authority in Kampala by the close of the day last Friday. However, the Permanent Secretary in the Ministry of Energy and Mineral Development, Frederick Kabagambe-Kaliisa told The EastAfrican in Kampala, "the evaluation is continuing. We are still making clarifications and administrative reviews. We usually encounter such problems when we call for tenders, so if complaints are being raised, it is not new." He added, "This is a joint tender for Uganda and Kenya. On our side, we have guiding principles and it is the law which is guiding us." However, under procurement regulations in both countries, once a petition is filed against a project, it remains suspended until the matter is resolved. But in its twin-pronged petition, Petronet EA Consortium first complained to the Ministers of Energy of Kenya and Uganda over matter. The complaint was then referred to the Joint Co-ordinating Commission on Pipeline Extension in a letter dated March 31. It was subsequently forwarded to the Public Procurement and Disposal Assets Authority in Kampala, whose executive director, Edgar Agaba, in a letter dated May 11, "advised" the Energy Permanent Secretary Kabagambe-Kaliisa to suspend the evaluation of the tender pending its administrative review for breach of procurement rules and guidelines. Similarly, Petronet on May 17 lodged a complaint with the Public Procurement Complaints, Review and Appeals Board over the decision of the Joint Commission eliminating it from the Technical Evaluation stage of the tender. The appeal in Kenya will be heard on June 12. This has delayed the construction of the 320-km pipeline from Eldoret to Kampala. Mr Agaba, in a letter to Mr Kabagambe-Kaliisa dated May 11, advised that the project be put on hold in line with Section 90 and Regulation 347 of the Authority's Act and Regulation, until it was resolved. He was responding to a query from the PS on whether the complaints raised by Petronet warranted an administrative review of the giant tender. Mr Kabagambe-Kaliisa and the PS in the Kenyan Ministry of Energy, Patrick Nyoike, form the Joint Commission on the Pipeline Extension. A key condition for the extension of the pipeline is that should any hitch arise on either side of the border, the project is stopped until the matter is resolved. About the letter from the Public Procurement and Disposal of Public Assets Authority, Mr Kabagambe-Kaliisa said, "I have received no such letter. Naturally, everything has been done according to law so I see no reason for us to go through the process again. When we are ready we shall announce the winner." Interestingly, even Mr Agaba said he has written no such letter, despite The EastAfrican giving him both the reference, date and subject. Petronet's complaint is not the first to hit the giant project. Both Zakhem ARB and Energem Petroleum Corporation of Canada have previously lodged protests at the manner in which the technical evaluations were being undertaken. All three firms were disqualified allegedly because their bids fell short of the technical bid specifications. In the case of Zakhem-ARB, the evaluation committee ruled that the insurance bond it had issued contained "conditions" instead of the required irrevocable bank guarantee specified in the tender documents. Surprisingly, the firm, which is owned by Lebanese nationals had earlier been cleared to square it out with the China Petroleum Pipeline Engineering Corporation, Tamoil East Africa Ltd and.
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These sums were payable in three equal installments, the first on the receipt of the location ticket, which was always obtained as soon as the Government had determined on the quantity of land to which the applicant was entitled. The second on filing a certificate of settlement duty, and a third, on receipt of the fiat for a patent. There were but few villages between York and Amherstburg, a distance of 326 miles, Dundas, Burford and Ancaster, were the only places which from the multitude of their inhabitants were considered as villages, and the whole population of the three together did not exceed 600 souls. The first houses erected in Burford village were located in the West end, between the old Cemetary and its present Western boundary. The townships educational establishments numbered two, one of which was located in the village of Burford and was opened in the year 1807. There were two stores, two taverns, three grist mills, four saw mills, one fulling mill, one carding machine, the cost of carding was Six pence per pound. Early H o t The accommodation provided for guests at the public houses in Upper Canada was of the most meager description. An early traveller who made the journey from London to York on foot, passing through Burford in the year 1820 has left the following account of the accommodation furnished him at this period"At Eight o'clock in the evening, I arrived at Dogge's tavern, where I put up for the night. Taverns in the country parts of.
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Pellet 3D ; did not appear as linear as in the Lischemia zone Fig. 3, A-C ; 25% MBF analysis of residuals revealed a failure of the predicted line to fit the observed data. Spline regression analysis was performed on H-control, M-ischemia, and Lischemia zones of untreated and MP-treated dogs. This analysis showed that the lines that were plotted for the H-control 75% MBF ; and M-ischemic 25% to 75% MBF ; zones were not significantly different from each other; however, the line of the 140, 000 g pellets of the L-ischemic zones 25% MBF ; were different P 0.05 ; from the H-control.
Methods of TCD in human transplantation have primarily depended on negative selection techniques by physical separation or antibody-based purging Figure 1 ; . Examples of physical separation techniques include differential agglutination with lectins followed by rosetting with sheep red blood cells, 27, 28 counterflow centrifugal elutriation, 29-31 and fractionation on density gradients.32 The earliest human trials using antibody as T depletion relied on absorbed ATG.33 However, this was soon replaced by monoclonal antibodies directed against specific targets on T cells. Monoclonal antibodies have been used alone, 34-36 and in conjunction with and fulvestrant.
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Introduction maize Xiao et al. The sustainability of agricultural systems is being confronted with a number of serious problems, including shortage of water resources, warming climate, and excessive exploitation of groundwater. In maize-growing regions in China, when drought stress occurs just before and during the flowering time, water stress results in increased length of the anthesis-silking interval and severe loss of yield Li et al., 2002 ; . Traditional breeding efforts for drought tolerance depended to a large extent on field tests of progenies, and accurate field evaluation is often laborious and difficult Ribaut et al., 1997 ; . Marker-assisted selection, which enables breeders to distinguish genotypes directly, can be a better approach to developing drought-tolerant germ plasm, a complex trait influenced by multiple genes. QTL analysis can dissect the genetic basis of the trait, enabling their use in markerassisted selection Tuberosa et al., 2002a ; . Complex traits can be dissected as Mendelian factors with molecular markers Paterson et al., 1988 ; . Agrama and Moussa 1996 ; investigated QTLs controlling grain yield under drought stress and detected 5 QTLs. Ribaut et al. 1997 ; examined QTLs for yield in tropical maize under 3 irrigation regimes, and 5 and 4 QTLs were detected under intermediate and severe stresses, respectively. These QTLs were unique to stressed conditions. Frova et al. 1999 ; identified 17 QTLs for yield components; more than 50% of them were also detected under wellwatered WW ; conditions, and some of them were common to 2 or more traits. Tuberosa et al. 2002b ; reported that the QTLs relevant to root traits at early stages also influenced grain yield in the field. About 74 QTLs for grain yield and more for yield components have been detected Maize Genetics and Genomics Database, 2003 ; . However, fewer QTLs were identified under water-stressed WS ; conditions. Considering the complexity of the physiological pathways of both yield and drought tolerance, it is necessary to identify and verify the QTLs based on different mapping populations. The objectives of this study were to identify QTLs relevant to yield and yield components, analyze the genetic effects, and reveal the relationships with the QTLs identified previously under water stress in different populations. Materials and Methods Plant materials and drought evaluation An F2 population of 234 plants derived from the cross X178 P1 ; B73 P2 ; was used to construct the genetic linkage map. The drought-tolerant X178 is a widely planted elite line in China. B73 is an elite line belonging to Iowa Stiff Stalk Synthetic heterotic group used in corn-growing regions in the United States. The corresponding F2: 3 families were evaluated for drought response in Shanxi province during the dry summer season in 2002. The phenotyping experiment.
Condition were attributed to the polychaetes. In Bathymodiolus puteoserpentis, the commensal polychaete had a prevalence of 30 to 40%. An even greater prevalence of the commensal polychaete was observed in B. heckerae from the Florida Escarpment seep site 60% ; . Branchipolynoe seepensis was not observed in B. heckerae from the Blake Ridge seep. In 3 Bathymodiolus heckerae from the Florida Escarpment, 4 nautiliniellid polychaetes possibly Laubierus mucronatus based on characteristics of the setae ; were observed in section Fig. 6b ; . The polychaetes were located between the ascending and descending filaments of the demibranchs. Little evidence of damage on the surrounding filaments was observed, although cells in the adjacent gill tissue were detached from the filament or the tissue was in poor condition; 3 of the polychaetes were infected with viral-like inclusions in the digestive tract Fig. 6c and fuzeon.
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Determinants of response to APO2 TRAIL in killing of normal and cancer cells. Clin Cancer Res. 2000; 6: 335-346. Sprick MR, Weigand MA, Rieser E, et al. FADD MORT1 and caspase-8 are recruited to APO2 TRAIL receptors 1 and 2 and are essential for apoptosis mediated by APO2 TRAIL receptor 2. Immunity. 2000; 12: 599-609. Kischkel FC, Lawrence DA, Chuntharapai A, et al. APO2 TRAIL dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. 2000; 12: 611-620. Gazitt Y, Shaughnessy P, Montgomery W. Apoptosis induced by APO2 TRAIL and TNF in human multiple myeloma cells is not blocked by bcl-2. Cytokine. 1999; 11: 1010-1019. Gazitt Y. APO2 TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. Leukemia. 1999; 13: 1817-1824. Liu Q, Gazitt Y. Adenovirus-mediated delivery of p53 results in a substantial apoptosis to myeloma cells and is not cytotoxic to flow-sorted CD34 hematopoietic progenitor cells and normal lymphocytes. Exp Hematol. 2000; 28: 1354-1362. Kim K, Takimoto R, Gazitt Y, et al. Enhanced APO2 TRAIL sensitivity by p53 overexpression in human cancer but not normal cells. Int J Oncol. 2001; 18: 241-247. Liu Q, El-Deiry W, Gazitt Y. Additive effect of Apo2L TRAIL and Adeno-p53 in the induction of apoptosis in myeloma cell lines. Exp Hematol. 2001; 29: 962-970. Wu GS, Burns TF, McDonald ER, et al. KILLER DR5 is a DNA damage-inducible, p53 regulated death receptor gene. Nat Genet. 1997; 17: 141143. Nagane M, Pan G, Weddle JJ, et al. Increased.
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Felt restricted in daily life because of frequent and urgent diarrhoea grade 2-3 ; , two had moderate defecation problems and the one with normal defecations had severe problems due to persistent fistulas grade 4 ; . Half of the patients had changed their diet, avoiding fiber-rich food cabbage, citrus ; , six used dietary supplements and three had a lower body weight than desired. All patients were able to take a daily walk and did not spend daytime in bed. Five assessed their health, total life situation or quality of life as "worse" than before the RT while two answered "unchanged". No patient chose the category "better". Three patients frequently had worries due to their health situation; e.g. stoma bags falling off fistula openings, urgent need for a toilet or new hospital stays and garlic!
He 20th annual Research and Clinic Day held recently at SDM, showcased students' research and provided the school the opportunity to award several students for their work. The event featured keynote speaker, Eleni Kousvelari, DSc, who discussed "Biometrics and Tissue Engineering: Enabling New Biomaterials." Kousvelari, an SDM alumna, is director of the Biomaterials, Biometrics, and Tissue Engineering Program of the Division of Extramural Research at the National Institute of Dental and Craniofacial Research at the National Institutes of Health. During the day, students exhibited their research and met with dental vendors to exchange product information. Approximately 30 pre- and postdoctoral students presented their research through oral or poster presentations, and awards were given to the best in each category. SDM Dean Spencer Frankl, DDS, MSD, presented award winners with certificates during the Clinic Night Banquet, held the following evening at the Royal Sonesta Hotel in Cambridge. In the pre-doctoral oral presentation category, Michael Dudi Fish, '03, received first place for "Long-Term Outcomes of Unerupted Third Molars." Esther Tam, '04, was awarded first place in the pre-doctoral poster presentation category for "Investigation of Environmental Regulation of Lactate Permease Gene Under Different pH Conditions." In the postdoctoral oral presentation category, Heloisa Gusman, DSc '00, received first place for "Histatin 5 Binding Affinities for Zinc and Copper, " and first place in the postdoctoral poster presentation category was awarded to Farnaz Fadavi, DMD, ENDO '02, for "Inorganic Hybrid Nanocomposite Dentinal Sealer and frova.
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