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DataStar Documents.1 Suicide among migrant populations and native Dutch in The Netherlands ; .1 . Ecological association between suicide rates and indices of deprivation in the north west region of England: the importance of the size of the administrative unit.1 Reducing suicidal ideation in depressed older primary care patients.2 . Suicides in the young people of Geneva, Switzerland, from 1993 to 2002.3 Suicide risk among persons with foreign background in Denmark 4 . Social work education in suicide intervention and prevention: an unmet need?.4 Cognitive vulnerability to depression, rumination, hopelessness, and suicidal ideation: multiple pathways to self-injurious thinking.5 Suicide in peacekeepers: risk factors for suicide versus accidental death 5 . Grief shortly after suicide and natural death: a comparative study among spouses and first-degree relatives.6 Examining the relationship between at-risk gambling and suicidality in a national representative sample of young adults.6 Sooner versus later: factors associated with temporal sequencing of suicide.7 Suicide by shooting and gun ownership licenses ; in Austria: Would gun restriction help?.8 Reduced brain leptin in patients with major depressive disorder and in suicide victims.8 Exponential fitting of suicide rate and national intelligence estimates 8 . Suicide rate and skin color.9 Suicidality and sexual orientation: differences between men and women in a general population-based sample from the Netherlands.9 Law & psychiatry: depressed? Get out!: dealing with suicidal students on college campuses.10 Haemorrhoids leading to post-mortem bleeding artefact 10 . Choking on toilet paper: an unusual case of suicide and a review of the literature on suicide by smothering, strangulation, and choking 11 . An unusual mechanical asphyxia in a homicide-suicide case by smothering and strangulation.12 Toxicologic findings in suicide: a 10-year retrospective review of Kentucky medical examiner cases 12 . Alcohol consumption and suicide among middle-aged men in Japan.13 Increased suicide risk among Danish women with non-melanoma skin cancer, 1971-1999.13 . An autopsy case of poisoning by neuropsychopharmaceuticals including zopiclone ; .14 Zopiclone fatality in a hospitalized patient.14 3 ; H ; Tiagabine binding to GABA transporter-1 GAT-1 ; in suicidal depression.15 Search Strategy.16.
Paint if scroll needed If checked the whole window is redrawn if a scroll is needed. When running a serial session with high speed 9600 bps ; characters may be lost due to some behavior of video drivers. Checking this flag bypasses the problem but slows down screen updating. Enable notes Show notes during establishing of connections. Use FTP passive Default flag is passive mode shall be used for FTP transfers or not. Show # during FTP Shows a number sign for every 1024 bytes that is transferred of a file. FTP Prompt mode A confirmation is needed for every file to transfer in MPUT and MGET commands during FTP.
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White et al. Ki values were calculated from the determined Vmax values of the control and test situation using the following equation: Ki I [Vmax V1max 1], where I is the inhibitor concentration, Vmax is the control value, and V1max is the value determined in the presence of inhibitor. GABA Release. Cerebral cortical neurons in culture were preloaded with [3H]GABA 1 M, 0.1 Ci ; for 30 min in the presence of 10 M vigabatrin to irreversibly inactivate GABA-transaminase, thereby blocking GABA metabolism Drejer et al., 1987; Gram et al., 1988 ; . Individual cultures 35-mm Petri dishes ; were subsequently placed in a superfusion apparatus Drejer et al., 1987 ; at 37C equipped with peristaltic pumps, and the cells were superfused at a flow rate of 2 ml min. Fractions from the outlet were collected every 30 s, and at the end of the experiments, radioactivity was determined in all fractions. During the superfusion, either 200 M nonradioactive GABA or 200 M EF1502 was added to the superfusion medium for 2 min. Results were expressed as counts per minute per fraction collected. It should be noted that since the baseline of the GABA release during the entire superfusion period was constant no major loss of intracellular [3H]GABA occurred during this period. Animals. Male albino CF no. 1 mice 18 25 g; Charles River Laboratories, Inc., Wilmington, MA ; and male and female Frings audiogenic seizure-susceptible mice 18 25 g; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT ; were used as experimental animals for studies conducted at the University of Utah. For these studies, all animals were allowed free access to both food S L Custom Lab Diet-7 ; and water except when they were removed from their cages for the experimental procedure. Mice were housed in a temperature and humidity controlled facility and were maintained on 12-h light dark cycle beginning at 6: 00 AM. Furthermore, all mice were housed, fed, and handled in a manner consistent with the recommendations in the Health, Education, and Welfare publication National Institutes of Health ; 86-23, Guide for the Care and Use of Laboratory Animals. Animals were euthanized in accordance with Public Health Service policies on the humane care of laboratory animals. For those studies conducted at H. Lundbeck A S, male Wistar rats 280 320 g at start of experiment ; from M&B Laven, Denmark ; were used for amygdala kindling. For the i.v. pentylenetetrazol PTZ ; and i.p. pilocarpine tests, male NMRI mice 18 22 g; M&B ; were used. All animals were allowed to adapt to the laboratory environment for at least 1 week prior to testing. Animals were housed on a 12-h light dark cycle, beginning at 6: 00 AM. All experiments were conducted between 8: 00 and 2: 00 PM. Experimental work was performed under a license from the Danish Ministry of Justice and in accordance with EC Directive 86 609 EEC and the Danish law regulating experiments on animals. The test substances were either suspended or dissolved in 0.5% methylcellulose by trituration in a mortar and pestle and sonicating for 10 min. All substances were administered i.p. or s.c. in a volume of 0.01 ml g body weight in mice and 0.05 ml g body weight in rats. Anticonvulsant Testing. The anticonvulsant profile of EF1502 was established by several different anticonvulsant tests that included audiogenic, 6-Hz psychomotor, amygdala kindled, PTZ, and pilocarpine seizures. Audiogenic Seizures. The ability of LU-32-176B, EF1502, and tiagabine to prevent sound-induced seizures in the Frings AGSsusceptible mouse model was assessed following i.p. administration. For each of the analogs examined, time-response curves were constructed using a dose that produced a submaximal anticonvulsant effect in a group of four mice per time point tested 5, 15, 30, and 120 min ; . Dose-response studies were then conducted at the subsequently determined time of peak effect of each test substance. For these studies, individual mice were placed into a Plexiglas cylinder diameter, 15 cm; height, 18 cm ; fitted with an audio transducer Model AS-ZC; FET Research and Development, Salt Lake City, UT ; and exposed to a sound stimulus of 110 decibels 11 KHz ; delivered for 20 s. Sound-induced seizures are characterized by wild running followed by loss of righting reflex with fore limb and hind.
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Results: tiagabine concentrations in blood and csf rose linearly and dose-dependently and time to maximum concentration tmax ; was 15 and 29 min, respectively.
Description: The Ulriksbanen cable car brings you to the top of Mount Ulriken 642 m. ; , which has Bergen's most magnificent view of the fjords, islands and coast. Well-marked trails the unspoiled mountain wilderness guides available. Free telescopes. The "Bergen in a Nutshell" sightseeing tour takes you along the harbour and Bryggen, through the historic town centre, up to mount Ulriken and back. This experience gives you wonderful insight into Norway's "secret capital"! You can choose between 8 languages in the bus and at the top of Mt. Ulriken. English guiding in the cable car. Restaurant with a breathtaking view on top. Licensed. Outdoor tables. How to get there: Double-decker sightseeing bus every 30 min., across from the Tourist Information Centre, from 09.15 till 20.45 May Sep Winter: Sats and Suns in good weather.
Background . 9 Need for the guideline. 10 Epidemiology. 10 Experience of those receiving care . 11 Woman and family centred care . 12 Aim of the guideline. 13 Scope . 15 For whom is the guideline intended . 15 Areas outside the remit of the guideline. 16 Related documents . 16 Responsibility and support for guideline development . 17 The National Collaborating Centre for Primary Care NCC-PC ; . 17 The Development Team. 17 The Guideline Development Group GDG ; . 18 Co-optees . 19 Guideline Development Group Meetings . 22 Care Pathway . 22 Research Recommendations . 28 Acknowledgements . 28 Glossary . 32 Action levels. 32 and timolol
Clinical Pearl Biotin for Brittle Nails Two thousand five hundred micrograms per day of biotin improved dry splitting nails for 63% of patients. The average time to noticeable results was 2 months. Cutis. 1993; 51: 303-305.
Sons.13, 19, 20 First, endogenous GABA synthesis and release with consequent reduction in GABAergic transmission are decreased after an ischemic insult. Second, since glutamatergic and GABAergic transmissions work by each counterbalancing the function of the other, enhancing GABAergic activity should balance excessive glutamatergic excitation, which is the pivotal event leading to cell death. The aim of the present study is to characterize the electrophysiological effects of 2 currently used GABAergic antiepileptic drugs, tiagabine and vigabatrin, and to examine the cellular sites at which they act by using recordings from rat corticostriatal slices. The mechanism of action of the 2 compounds is different. Vigabatrin is an irreversible inhibitor of GABA transaminase, 21, 22 whereas tiagabine blocks GABA reuptake into neurons and glia.23 Their possible differential abilities in protecting neurons against the permanent loss of electric activity caused by combined oxygen and glucose deprivation have been investigated. We have also analyzed the effects of other specific GABAA and GABAB agonists and antagonists and ting.
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Fig. 1. Western blot of crude sonicates of brain tumours with varying ATase activity lanes 2-7; see Table I ; and recombinant human ATase rH ; probed with the anti-human ATase polyclonal antibody. The positions of the molecular weight markers are shown. See text for experimental details.
From the Lymphoma Working Committee of the International Bone Marrow Transplant Registry Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee; University of Chicago, IL; University of Nebraska Medical Center, Omaha; University of California, La Jolla; University of Minnesota, Minneapolis; University of Texas, Health Science Center, San Antonio; Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Mayo Clinic and Foundation, Rochester, MN; Bristol Children's Hospital, Bristol, United Kingdom; Hospital Sant Creu I Sant Pau, Barcelona, Spain; Oregon Health and Sciences University, Portland; City of Hope National Medical Center, Duarte, CA; Fundacion Para Combatir La Leucemia FUNDALEU ; , Buenos Aires, Argentina; The Cancer Center at Hackensack University Medical Center, NJ; University Hospital Maastricht, the Netherlands; University of North Carolina, Chapel Hill; and Case Western Reserve University Hospital, Cleveland, OH. Submitted April 17, 2003; accepted July 14, 2003. Prepublished online as Blood First Edition Paper, July 31, 2003; DOI 10.1182 blood-2003-04-1205. Supported by Public Health Service grant U24-CA76518 from the National Cancer Institute, the National Institute of Allergy and Infectious Diseases, and the National Heart, Lung, and Blood Institute; and grants from Allianz Life Life Trac; American Cancer Society; American Red Cross; American Society of Clinical Oncology; Amgen, Inc; Anonymous; Aventis Pharmaceuticals; Baxter Healthcare Corp; Baxter Oncology; Berlex Oncology; Biotransplant Inc; Blue Cross and Blue Shield Association; The Lynde and Harry Bradley Foundation; Bristol Myers Squibb Oncology; Cedarlane Laboratories Ltd; Cell Pathways; CelMed Biosciences; Centocor, Inc; Cubist Pharmaceuticals; Darwin Medical Communications, Ltd; Dynal Biotech ASA; Edwards Lifesciences RMI; Endo and tinzaparin.
Laboratory criteria for confirmation include: 1 ; PCR identification of variola DNA in a clinical specimen, or 2 ; isolation of smallpox variola ; virus from a clinical specimen World Health Organization Smallpox Reference Laboratory or laboratory with appropriate reference capabilities ; with variola PCR confirmation. The importance of case confirmation using laboratory diagnostic tests depends on the epidemiological situation. Laboratory diagnosis of tularemia is based on culture or serology. F. tularensis is a slow-growing, fastidious organism that requires media containing cystine or cysteine for optimal growth. Laboratory personnel should be alerted if tularemia is suspected to ensure that proper media are used and to prevent infection of laboratory workers. Serologic testing is available through reference laboratories. Confirmation requires a 4-fold change in anti-F. tularensis antibodies between paired sera.
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Figure 1. The effect of food deprivation and diet composition on the serum concentration of T3 and rT3 in humans. Data represent means SEM for six subjects. Fasting produces reciprocal changes in these thyronines that are reversed by refeeding a mixed diet. A protein diet has no effect on the concentration of T3 but partially restores that of rT3. Drawn from data published by F. Azizi, Metabolism, 27: 935, 1978, with permission of the author ; The basal serum TSH level during calorie deprivation is either normal or low, the response to TRH is blunted[37-39] and the normal nocturnal rise in TSH is blunted.[40a] These changes are quite surprising given the consistent and profound decrease in serum FT3 levels. Several hypothesis have been proposed to explain this paradox. Because the pituitary is able to continue to respond appropriately during fasting to both suppressive and stimulatory signals, [56] it has been suggested that starvation only "resets" the set point of feedback regulation. A more plausible hypothesis, supported by experimental data, [57, 58] proposes that the pituitary is regulated by the intracellular concentration of T3, which may remain unaltered through factors ensuring its continuous local generation during starvation, whereas a decrease is typically found in other tissues. Further support for this hypothesis comes from a recent study demonstrating that fasting produces a marked increase in hypothalamic Type II Deiodinase mRNA[58a] which would enhance local T3 production. This hypothesis gives credence to the preservation of a closer inverse relationship between serum FT4 and TSH than between FT3 and TSH. 4 and tipranavir.
Patient disposition for the study is presented in Fig. 1. Of 404 patients screened at study entry, a total of 321 patients met the criteria for study entry and were randomized, 160 to the Bio-HA group and 161 to the CL-HA group. Of the 83 patients not meeting the trial's inclusion or exclusion criteria, 17 were excluded because they did not meet the inclusion criteria for WOMAC Index pain scores at baseline. Of.
Data are taken from Fig. 7, AC. Data represent the mean CLtotal CLrenal, plasma ml min kg S.E. n 3 ; . CLrenal, kidney GFR Kp, kidney Kp, liver Kp, brain and tobi.
The stainless steel tubing and polyethylene tubing, exiting near the distal end through a small hole that was then glued. At the proximal end of the probe, a 4 mm dialysis membrane with one end occluded was inserted over the silica tubing protruding from the stainless steel tubing and was sealed to it. The dialysis membrane was Qupra-ammoniumrayon with a molecular mass cut-off of 40, 000 Da and a diameter of 250 m Asahi Medical, Tokyo, Japan ; . The dimensions of the membrane exchange area at the tip of the microdialysis probe were 2.0 mm x 0.3 mm length x diameter.
Ing this transitional phase, English-speaking American culture also exerted a powerful attraction. In the New World, many groups continued to use their native languages and worship in their own churches. They often formed social clubs and political associations with other members of their ethnic group. Some founded schools in which children born in America would be taught the language of their and tolcapone.
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Inter-individual variation. There is also a potential contribution of blunted neural input from atrophied stretch receptors in chronically distended atriopulmonary beds, which has been well-demonstrated in dog models of chronic volume overload 10 ; . In addition to all of the other factors involved, it is likely that the cardiorenal interactions will demonstrate strong influence from genetic polymorphisms that affect neurohormonal responses and sodium avidity, as has been observed for hypertension 9 ; . Pre-existing renal impairment accelerates disease progression at all stages. Untangling the cardiorenal syndrome in humans is further complicated because progression has occurred in the milieu of chronic neurohormonal antagonists and diuretic therapy, which stimulate chronic compensatory responses 11 and tiagabine
Marketed as keppra ; , oxcarbazepine marketed as trileptal ; , pregabalin marketed as lyrica ; , tiagabine marketed as gabitril ; , topiramate marketed as topamax ; , valproate marketed as depakote, depakote er, depakene, depacon ; and zonisamide marketed and tolmetin.
Hydrogenase 3 -HSD ; gene of a female patient with nonsalt-losing 3f3-HSD deficiency. J Clin Endocrinol Metab 78561-567 Pang S, Lemer A, Stoner E, Levine LS, Oberfield SE, Engel I, New MI 1985 Late-onset steroid 3P-hydroxysteroid dehydrogenase deficiency. I. A cause of hirsutism in pubertal and postpubertal women. J Clin Endocrinol Metab 60: 428-436 Siegel SF, Finegold DN, Lanes R, Lee PA 1990 ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism. N Engl J Med 323849-854 Eldar-Geva T, Hurwitz A, Vecsei P, Palti Z, Milwidsly A, Rosler A 1990 Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia. N Engl J Med 323855-863 Pang S, Softness 8, Sweeney W, New MI 1987 Hirsutism, polycystic ovarian disease, and ovarian 17-ketosteroid reductase deficiency. N Engl J Med 316: 1295-1301 Toscano V, Balducci R, Bianchi P, Mangiantini A, Sciarra F 1990 Ovarian 17-ketosteroid reductase deficiency as a possible cause of ~olvcvstic ovarian disease. 1 Clin Endocrinol Metab 71: 288-292 ink&r SE, Brodie AMH 1991 Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: an immunocytochemical study. J Clin Endocrinol Metab 73: 717-726 Franks S, Mason HD 1991 Polycystic ovary syndrome: interaction of follicle stimulating hormone and polypeptide growth factors in oestradiol production by human granulosa cells. J Steroid Biochem Mol Biol40: 40! + 409 Erickson GF, Garzo VG, Magoffin DA 1989 Insulin-like growth factor I regulates aromatase activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab 69: 716-724 Erickson GF, Magoffin DA, Cragun JR, Chang RJ 1990 The effects of insulin and insulin-like growth factors I and II on estradiol production by granulosa cells of polycystic ovaries. J Clin Endocrinol Metab 70~894-902 Shimasaki S, Shimonaka M, Ui M, Inouy S, Shibata F, Ling N 1990 Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. J Biol Chem 265: 2198-2202 Brailly S, Gougeon A, Milgrom E, Bomsel-Helmreich 0, Papiemik E 1981 Androgens and progestins in the human ovarian follicle: differences in the evolution of preovulatory, healthy nonovulatory and atretic follicles. J Clin Endocrinol Metab 53: 128-X34 Hillier SG, van den Boogard AJM, Reichart Jr LE, van Hall EV 1980 Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5a-reduced Cl9 steroids inhibit the aromatase reaction in vitro. J Endocrinol84: 409-419 Hillier SG 1987 Intrafollicular paracrine function of ovarian androgen. J Steroid Biochem 27351-357 Haning Jr RV, Hackett RJ, Flood CA, Loughlin JS, Zhao QY, Longcope C 1993 Testosterone, a follicular regulator: key to anovulation. J Clin Endocrinol Metab T7: 710-715 Conte FA, Grumbach MM, Ito Y, Fisher CR, Simpson ER 1994 A syndrome of female pseudohermaphroditism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase P450arom ; . J Clin Endocrinol Metab 781287-1292 Richards JS, Jonassen JA, Kersey KA 1980 Evidence that changes in tonic luteinizing hormone secretion determine the growth of preovulatory follicles in the rat. Endocrinology 10764-648 Richards JS, Bogovich K 1982 Effects of human chorionic gonadotropin and progesterone on follicular development in the immature rat. Endocrinology 111: 1429-1438 Gougeon A 1986 Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod 1: 81-87 Kamrava MM, Seibel MM, Berger MJ, Thompson I, Taymor ML 1982 Reversal of persistent anovulation in polycystic ovarian disease by administration of chronic low dose follicle-stimulating hormone. Fertil Steril37: 520-523 Polson DW, Mason HD, Saldahna MBY, Franks S 1987Ovulation of a single dominant follicle during treatment with low-dose pulsatile follicle stimulating hormone in women with polycystic ovary svndrome. Clin Endocrinol Oxfl 26: 205-212 Poison DW, Mason HD, Kiddy DS 1989 Low-dose follicle-stimulating hormone in the treatment of polycystic ovary syndrome: a.
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The major observation made in this study is that a subset of neurons in the nodose ganglion may give rise to a dense plexus of irCART fibers in the NTS and that CARTp administered intracisternally or directly into the NTS attenuated PE-induced bradycardia, whereas CART antiserum injected into the NTS potentiated PE-induced bradycardia. It is well established that vagal afferents project to the NTS and that the NTS is the predominant site of autonomic cardiovascular control. Lesions or other perturbations to the NTS result in increased arterial pressure 11, 22 ; . Previous immunohistochemical and in situ hybridization studies show that irCART is present in fibers of the NTS and in neurons of the vagal nerves, respectively 3, 9, 14 ; . Our immunohistochemical results confirm the presence of a dense plexus of irCART and toradol.
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