Dantrolene and neuroleptic malignant syndrome
Activating subscriptions document delivery linking to ingentaconnect alerting & rss feeds other library services keeping in touch register dantrolene - a review of its pharmacology, therapeutic use and new developments authors: krause, 1 ; gerbershagen, u.
Conclusions: In a part of the hemiplegics, motor perception may be disabled. We can discriminate them by this method with personal computers. Distributable examination program can make multifacility joint research easier and make it possible to gather the large numbers of subjects.
Ali, S., Pellegrini, I. and Kelly, P.A. 1991 ; A prolactin-dependent immune cell line Nb2 ; expresses a mutant form of prolactin receptor. J. Biol. Chem., 266, 2011020117. Alila, H.W., Rogo, K.O. and Gombe, S. 1987 ; Effects of prolactin on steroidogenesis by human luteal cells in culture. Fertil. Steril., 47, 947955. Boutin, J.M., Jolicoeur, C., Okamura, H. et al. 1988 ; Cloning and expression of the rat prolactin receptor, a member of the growth hormone prolactin receptor gene family. Cell, 53, 6977. Boutin, J.M., Edery, M., Shirota, M. et al. 1989 ; Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells. Mol. Endocrinol., 3, 14551461. Clarke, D.L., Arey, B.J. and Linzer, D.I. 1993 ; Prolactin receptor messenger ribonucleic acid expression in the ovary during the rat estrous cycle. Endocrinology, 133, 2594603. Clevenger, C.V. and Plank, T.L. 1997 ; Prolactin as an autocrine paracrine factor in breast tissue. J. Mamm. Gland Biol. Neoplasia, 2, 5968. Clevenger, C.V., Freier, D.O. and Kline, J.B. 1998 ; Prolactin receptor signal transduction in cells of the immune system. J. Endocrinol., 157, 18797. Cox, D.B., Kent, J.C., Casey, T.M. et al. 1999 ; Breast growth and the urinary excretion of lactose during human pregnancy and early lactation: endocrine relationships. Exp. Physiol., 84, 42134.
Updated information and services can be found at: : bloodjournal.hematologylibrary cgi content full 105 10 4143 Articles on similar topics may be found in the following Blood collections: Transplantation 1255 articles ; Immunotherapy 571 articles ; Brief Reports 1018 articles ; Clinical Trials and Observations 2313 articles ; Neoplasia 3910 articles ; Information about reproducing this article in parts or in its entirety may be found online at: : bloodjournal.hematologylibrary misc rights.dtl#repub requests Information about ordering reprints may be found online at: : bloodjournal.hematologylibrary misc rights.dtl#reprints Information about subscriptions and ASH membership may be found online at: : bloodjournal.hematologylibrary subscriptions index.dtl.
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J.A28037 03 had a large practice. Dr. Harmon felt that "due to the large practice he had, and the relationship he had with his patients, [Dr. Harmon] saw no reason why [appellant] couldn't continue to see them [the patients]." N.T. 4 3 02, p. 189. Dr. Harmon testified that he provided appellant with usable blank prescriptions by crossing out appellant's name and signing his name and placing his DEA number on appellant's blank prescription pads. Appellant had been informed by Agents Walczak and Rucker that without a valid license to practice medicine, he was not entitled to a DEA license and number. ; Any prescription for controlled substances written without a valid DEA number could not lawfully be filled by any pharmacy. Thus, appellant needed to use Dr. Harmon's DEA number if he was to continue to write prescriptions for regulated drugs. Dr. Harmon was compensated by a payment of 00 for one week, plus one quarter of Dr. Harmon's malpractice insurance premium. From January 29, 2001, through February 10, 2001, Dr. Harmon worked for appellant, Monday through Friday from 9: 00 a.m. until 1: 00 p.m. On February 11, 2001, Dr. Harmon left for Florida.3 Dr. Harmon testified at trial that he never saw patients or prescribed any medication for patients. N.T. 4 3 02, p. 192-93. Dr. Harmon did review patient files because his name was on the prescriptions. Dr. Harmon spoke with appellant about his concerns with the many prescriptions given for OxyContin, a drug that Dr. Harmon knew little about except that it was used in the treatment of pain and had a potential for abuse similar to Percocet. N.T. 4 3 02, p. 194 and dapsone.
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GPL ABBR: General Public License grain RT: granularity n. ~ 1. pattern or structure in materials caused by the alignment of component fibers or particles. 2. A design embossed on a surface to imitate a natural pattern. 3.PHOTOGRAPHY The relative coarseness of an image that results from the size of silver particles in the emulsion. Notes Grain3 is usually invisible to the naked eye. It becomes more visible as a negative is enlarged; prints made from small negatives are generally grainer than prints of the same size from a larger negative. Grain is generally more pronounced in high-speed emulsions. granularity RT: grain n. ~ 1. PHOTOGRAPHY An objective measure of variation in density caused by the size of particulate silver or dyes that give the appearance of grain3. 2. The degree to which data is broken up into its most elemental components. graphic RT: image n. ~ 1. image; an illustration. 2. A symbolic representation of something. 3. CATALOGING A still, two-dimensional representation intended to be viewed by reflected light. Notes A graphic, generally, may be two or three dimensional. It may be a component in a larger work, or an independent work. Graphic1 is not necessarily representational; it may be colors and shapes that do not attempt to depict the appearance, abstract or precise, of any real world object or scene. Graphic2 may be used to describe something that is a pictorial representation of the world, or an abstract representation of ideas through the positioning of shapes, lines, words, or other visual devices. Citations [Graphic3] A two-dimensional representation whether opaque e.g., art original and reproductions, flash cards, photographs, technical drawings ; or intended to be viewed, or projected without motion, by means of an optical device e.g., film strips, stereographs, slides ; . [Glossary of Terms Related 100 ; ] Graphic Interchange Format ABBR: gif graphic records RT: photograph, picture n. ~ A broad class of records that are primarily images, as distinguished from textual records. Notes Graphic records may include architectural, engineering, or artistic works, and may be drawings, designs, photographs, sketches, or other media. gray card SEE: neutral test card and daptomycin.
The PCA Division is very interested in facilities that have an established process for Nursing Peer Review. If your hospital has a Nursing Peer Review Committee or a similar structure already in place, we would like to hear from you. We would appreciate a brief summary of your processes that guide Nursing Peer Review. Included in this summary should be: whether case identification is from retrospective review, concurrent review, or by referral from a medical staff committee; any impacts that the quality review analysis by nursing has had on patient safety at your facility; and any other information that is pertinent. Please submit your responses via e-mail only to: Barbara.Watts state.ma.
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Mutations 19 24 ; . The pathophysiological consequences of MH mutations are hyperactivation and or hypersensitization of RyR1 Ca2 channel activity to stimulating conditions both pharmacological and voltage-dependent ; 1, 18 ; . In contrast, most mutations conferring susceptibility to central core disease, a rare myopathy showing a different phenotype 19, 25, 26 ; , are located in the C-terminal putative channel pore region Ile3916Ala4942 ; 19, 26 ; . The Ca2 release properties of expressed RyR1 channels containing randomly selected MH mutations from the N-terminal and central domains have been shown to display similar properties of hyperactivation and hypersensitization 27 ; . To explain these results, we have proposed a model of channel regulation that involves interdomain interactions between the N-terminal and central domains of RyR1 serving as a "domain switch" for Ca2 channel regulation 28 31 ; . the resting state, the N-terminal and central domains make close contact at several as yet undetermined subdomains. The conformational constraints imparted by the "zipped" configuration of these two domains stabilize and maintain the closed state of the Ca2 channel. Stimulation of the RyR via excitation-contraction coupling weakens these critical interdomain contacts unzipping of the domain switch ; , thereby lowering the energy barrier for Ca2 channel opening. Partial unzipping or weakening of the domain switch may also occur secondary to MH mutations in either the N-terminal or central domain. As a result of this, MH-susceptible RyR1 channels are hypersensitive to agonist stimuli. Recently, Parness and co-workers 32 ; localized a dantrolene-binding site within the primary structure of RyR1 using [3H]azidodantrolene, a pharmacologically active photoaffinity analog of dantrolene. [3H]Azidodantrolene specifically photolabels the N-terminal 1400-amino acid fragment of RyR1 cleaved by an endogenous, SR membrane-bound calpain 33 ; and is localized within sequence Leu590Cys609 based on the following evidence. 1 ; Of several synthetic RyR1 domain peptides examined, [3H]azidodantrolene specifically photolabels only peptides containing the Leu590Cys609 sequence named DP1 for domain peptide-1 ; , and 2 ; an anti-RyR1 monoclonal antibody recognizing DP1 inhibits [3H]azidodantrolene photolabeling of RyR1 34 ; . The dantrolene-binding site is therefore located within the domain comprising the N-terminal portion of our proposed domain switch. Since dantrolene seems to inhibit Ca2 release, these findings have led us to suggest that dantrolene may act by reinforcing interactions between the Nterminal and central portions of the RyR1 domain switch that favor a zipped conformation. Here, we present new evidence suggesting that this is indeed at least a portion of the mechanism of action of dantrolene. In this study, we produced MH-like conditions of RyR1 i.e. hyperactivation and hypersensitization of Ca2 channels ; in SR isolated from normal skeletal muscle by adding DP4, a synthetic domain peptide corresponding to amino acids 2442 2477 of RyR1, or anti-DP4 antibody, which, as we have recently shown, induces spectroscopic changes consistent with domain unzipping 29, 31 ; . The magnitude of domain unzipping was determined from the accessibility of a fluorescence probe, methylcoumarin acetate MCA ; , attached to the N-terminal domain, to a macromolecular fluorescence quencher bovine serum albumin-conjugated QSY ; . The Stern-Volmer quenching constant KQ ; , a measure of domain unzipping, increased with the addition of either DP4 or anti-DP4 antibody. Here, we show that the addition of dantrolene reversed the increase in KQ that was produced by DP4 or anti-DP4 antibody with an IC50 of 0.3 M. This blocking effect of domain unzipping by dantrolene was present at both 37 and 22 C and was independent of calmodulin CaM ; . Although, at 37 C, dantrolene alone inhibited DP4 and darifenacin.
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Xenopus oocytes. We tested CFTR, ClC-1, ClC-5, the oocyte's endogenous Ca + -activated Clchannel eCaCC ; , and MOD-1, a serotonin-gated Cl- channel 24, 52, 61, ; . Transfected oocytes exhibited currents with mean reversal potentials between -25 and -30 mV, consistent with selective Cl- conduction not shown ; . Although these channels exhibited divergent voltageand ligand-dependencies as well as differing levels of expression on oocytes, none were measurably inhibited by 50 M dantrolene Fig. 5 ; , the limit of its solubility under these conditions and some 45 times its K0.5 for inhibition of PSAC-mediated sorbitol lysis. In contrast, previously known PSAC antagonists are less specific. 50 M glybenclamide produced 60% inhibition of CFTR mean of n 3 cells, data not shown ; , consistent with previous studies 60 ; . NPPB is also known to have broad activity against these and other anion channels 24 and deferasirox.
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