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Only those needed for the main dramatic presentation. T h e Presenter pethe gura ; taken from the nadagam became n an important figure i setting the scene for each episode. A full-fledgedchorus took u p the refrains of the characters as they sang on the stage. Music was supplied by a group of full-time musicians. With these refinements this n e w play of great dramatic intensity, based o n the simple kolam story M a n without changing the characters or the story intrinsically, provided an entirely satisfying, colourful and tuneful drama. T h e play began its career w t indifferent audiences because it opened to the small ih sophisticated audience w h o that time were the chief patrons of Sinhalese drama, but soon, w h e n the play was taken before the mass of the people, its popularity was immediate. T i was the first conscious effort to evolve somehs thing lasting and worth while from traditional material and its popularity was evidence of two facts: first, properly handled by a competent dramatist, the traditional material could lend itself to good drama; second, the people were prepared to applaud this variety of play as something of their own, going back to something of indigenous cultural value. Sarathchandra's M a n contained lyrics of great beauty and this was of special appeal to the audience. T h e conventional movements of the characters on the stage n and the lilting dialogue became attractive i their very simplicity and brevity. Good sincere acting also contributed, of course. It m a said that the very great popularity itself of M a was the cause of the undoing of its technique. A host of imitators followed without conspicuous success, until Sarathchandra himself wrote another play more brilliant than even M a n very serious theme, w t university students as actors again. ih This was Sinhabahu, staged for the first time i 1961. n Based o n the legend of the origins of the Sinhala race, he n wrote a moving drama i which the lion father w h o obtained a royal princess for his wife and the son and n daughter born to them got involved i very serious genuine.
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HTN-induced renal damage compared to WT controls. Thus, the aim of this study was to determine the mechanism and functional significance of this enhanced HTN-induced renal damage. We previously demonstrated by telemetric recording that the DOC-salt HTN produces a similar 35% increase in MAP in both CGRP KO and WT mice. CGRP KO and WT mice were studied at 0, 14, 21, and 42 days following DOC-salt HTN. Renal sections from DOC-salt WT mice showed no pathological changes at any time point studied. However, by day 14, DOC-salt CGRP KO mice showed 2 scale of 1 to glomerular proliferation and crescent formation and tubular protein casts. On days 14, 21, and 42, kidney sections from the DOC-salt CGRP KO mice showed progressive increases in the inflammatory markers ICAM-1 and VCAM-1. Monocyte chemoattractant protein-1 expression was detected at day 21, and increased from 2 to 4 between days 21 and 42. There was a significant increase in 24 hr urinary isoprostane, a marker of lipid peroxidation, levels at days 14, 21, and 42 in the DOC-salt CGRP KO 14, 695 - 17.4; 21, 725 - 23; 42, 753 -4 ng ml 24 which was greater compared to the DOC-salt WT mice 336 -12; 21, 349 - 44; 42, 338.7 -18 ng ml 24 hr, all p 0.01 ; . Urinary microalbumin was significantly higher at day 21 for DOC-salt CGRP KO compared to DOC-salt WT mice 34.3 - 9 vs. 14.9 -3 ug ml 24 hr, p 0.01 ; . Microalbumin values for the CGRP KO and WT controls were 4.9 - 3 and 6.6 -1 ug ml 24hr, respectively. In addition, creatinine clearance ml min ; was significantly decreased in the DOC-salt CGRP KO compared to the DOC-salt WT mice. As a percent of baseline, creatinine clearance in the DOC-salt WT mice was 0.477 -.05% compared to DOC-salt CGRP KO mice with a creatinine clearance of 0.093 -.01% p 0.01. Therefore, in the absence of a-CGRP, DOC-salt HTN induces enhanced oxidative stress leading to inflammation, renal histopathologic damage, and reduced renal function. Thus, sensory nerves, via a-CGRP, are renoprotective against HTN-induced damage.
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He University of Pittsburgh Movement Disorders Center is currently conducting research to determine whether manifestations of Parkinson disease can be identified before symptoms develop. At this time, the research is focusing on first-degree relatives of PD patients, particularly brothers and sisters. The initial testing is simple, including an examination, tests of balance, motor function, smell, and paper and pencil tests. Subjects will be compensated for their time and effort. For more information, call Dana Ivanco, clinical research coordinator at 412-692-4665 and fluoride.
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Metabolism of these malignant cells and the products of necrosis in the tumor itself. Therefore, steroids may be effective in the edema of gliomas by acting as an anti-inflammatory agent and secondarily by protecting the cells from the effects of compression and irritation. It is presumed that cortisol and other antiinflammatory steroids exert their action in pharmacological concentrations by stabilizing the membrane of lysosomes against the disruptive influences of hypoxia and chemical toxins.29 It has been speculated that the glucocorticoids suppress inflammation by restraining the hydrolases to the lysosomes. In this regard, a recent important work by Clendenon et al.30 and a subject review of cerebral metabolism by Allen27 should be considered. Lysosomes are contained in the central nervous system primarily in the neurons and not in the glial cells. This does not coincide with the early swelling of the glial cells in the electron microscopy studies of standard models for experimental edema and the edema of ischemia. Clendenon et al. indicated in their model of anoxic-ischemic edema that early release of lysosomal enzymes was minimal and occurred after three hours at a time when it was not a decisive factor in the pathogenesis of cell injury in the nervous system. In a compressive lesion, the situation is different and lysosomes could be an early factor. There is little clinical evidence28 and no laboratory data from our study or from previous investigations31'32 to support the use of steroids for the edema associated with cerebral ischemia or infarction from single major vessel occlusion. Large dosages of these drugs cannot be considered innocuous, and the unproved potential benefit is overbalanced by the known risk of the drugs in the dosages commonly employed.
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Scale. In all studies, galantamine conferred a statistically significant benefit to participants when compared with placebo. The benefit varied depending on the dose of galantamine. Four RCTs that assessed treatment with galantamine at a dose of 24 mg were combined by the Assessment Group in a meta-analysis. The fixed-effects model showed a weighted mean difference of 3.28 95% CI 3.89 to 2.67 ; , representing a statistically significant improvement following treatment with galantamine versus placebo. 4.1.3.3 Six RCTs assessed the effect of galantamine compared with placebo on the CIBIC-plus scale. They showed that, in individual studies, more participants on galantamine improved than on placebo 0-6.5 percentage points more ; , whereas more participants on placebo than on galantamine deteriorated 4-18 percentage points more ; . When the studies were pooled by the Assessment Group aggregate number of people randomised 2294 ; no statistical significance was noted between treatment groups and placebo. 4.1.3.4 The results of five RCTs showed that participants receiving galantamine at dosages of 1632 mg day had statistically significantly less deterioration than those receiving placebo, as assessed using scales that measure activities of daily living. 4.1.3.5 In one RCT, higher dosages of galantamine 16 mg day or over ; were associated with a statistically significant slowing in the deterioration of participants' behavioural condition compared with placebo, as assessed using the NPI scale. In two trials, the slowing of deterioration was not statistically significantly different between galantamine and placebo groups. 4.1.3.6 Across RCTs, between 2 and 27 percentage points more participants on galantamine experienced an adverse event compared with those on placebo. Between 6% and 44% of participants receiving galantamine and flurazepam.
Written informed consent was obtained from 24 healthy male subjects, 24.5 1.2 yr old, with a body mass index of 23.1 0.6 kg m2. They had no abnormalities on physical examination and on routine chemical and hematological laboratory tests and were without family history of diabetes mellitus or gastric ulcer disease; they were on no medication and did not perform vigorous exercise during the study period. The study protocol was reviewed and approved by the ethical committee of the Basel University Hospital.
| Flu clinic flumist marylandTablet manufacturing differs from practical condition to a large extent and does not consider some critical tabletting parameters such as porosity, tablet hardness and versatility of process conditions. Data generated from such systems require sufficient scaling up and should not be directly extrapolated to commercially prepared controlled release tablets and flurbiprofen.
Among the factors that could cause actual results to differ materially are: seasonal demand for and continued supply of our principal product, synagis; whether flumist receives clearance by the food and drug administration and, if it does, whether it will be successfully launched at a favorable price; availability of competitive products in the market; availability of third-party reimbursement for the cost of our products; effectiveness and safety of our products; exposure to product liability, intellectual property or other types of litigation; foreign currency exchange rate fluctuations; changes in generally accepted accounting principles; growth in costs and expenses; the impact of acquisitions, divestitures and other unusual items; and the risks, uncertainties and other matters discussed in medimmune's annual report on form 10-k for the year ended december 31, 2001 and in its periodic reports on forms 10-q and 8-k filed with the securities and exchange commission.
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Introduction: The cerebrovascular reactivity CVR ; is a haemodynamic parameter which represents normal cerebral artery blood flow increase in response to a vasodilatory stimulus, such as hypercapnia. The aim of the study was to assess the CVR by transcranial Doppler TCD ; ultrasound and the breath-holding test BHT ; in normotensive patients p ; with non-insulindependent diabetes mellitus NIDDM ; . The cerebrovascular response to hypercapnia was evaluated in relationship with risk factors for cerebral microangiopathy. Methods: The study was carried out in a group of 34 normotensive NIDDM p and a group of 31 gender- and age-matched normal controls NC ; . The group of NIDDM was divided in a subgroup A of 21 with microangiopathic complications; 12 males, 9 females; mean age and fluvastatin
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More than 200, 000 people are hospitalized from influenza virus complications and about 36, 000 people die from the flu each year, according to the Center for Disease Control and Prevention. With flu season upon us, it won't be long until the virus causes aches and pains in those unlucky enough to catch the nasty bug, but there is good news for those looking to battle the perennial disease. The single best way to protect against the flu is to get vaccinated each fall, according to the CDC Web site at cdc.gov. Flu shots and the Flumist are available at Naval Hospital Beaufort, and active duty personnel can have the shot administered at Marine Corps Recruit Special to The Boot Depot Parris Island or Fluzone is a vacMarine Corps Air Station cine that is injectBeaufort. ed. Flumist is Fluzone an inactivated inhaled through vaccine, containing killed the nostrils. virus is given with a needle, usually in the arm. The flu shot is approved for use in people older than 6 months, including healthy people and people with chronic medical conditions, according to Catherine Colby, a registered nurse in charge of the immunization clinic at Naval Hospital Beaufort. About two weeks after vaccination, antibodies that provide protection against the flu virus infection will develop in the body and last six months to one year, said Colby. Like with any vaccine, some symptoms or side effects may occur for a short period of time, but "this is not going to give you the flu, " said Colby. There is also a form of the flu vaccination that is both non-invasive and virtually painless, called "Flumist." Flumist, a nasal-spray flu vaccine, is made with live, weakened flu viruses that do not cause the flu. The Flumist is also sometimes called LAIV for "Live Attenuated Influenza Vaccine." LAIV is approved for use in healthy people 5 years to 49 years of age, who are not pregnant, according to the CDC. Unlike the flu shot, this vaccine is not subject to prioritization and can be given to healthy 5- to 49-yearolds at any time and focalin.
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References Alterman RL, Reiter GT, Shils J, Skolnick B, Arle JE, Lesutis M, et al. Targeting for thalamic deep brain stimulator implantation without computer guidance: assessment of targeting accuracy. Stereotact Funct Neurosurg 1999; 72: 1503. Alvarez L, Macias R, Lopez G, Alvarez E, Maragoto C, Teijeiro J, et al. Bilateral subthalamotomy in Parkinson's disease. Mov Disord 2000; 15 Suppl 3 ; : 65. Alvarez L, Macias R, Guridi J, Lopez G, Alvarez E, Maragoto CT, et al. Dorsal subthalamotomy for Parkinson's disease. Mov Disord. 2001; 16: 728. Baron MS, Vitek JL, Bakay RA, Green J, Kaneoke Y, Hashimoto T, et al. Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol 1996; 40: 35566. Baron MS, Sidibe M, DeLong MR, Smith Y. Course of motor and associative pallidothalamic projections in monkeys. J Comp Neurol 2001; 429: 490501. Baunez C, Amalric M, Robbins TW. Enhanced food-related motivation after bilateral lesions of the subthalamic nucleus. J Neurosci 2002; 22: 5628. Benabid AL, Pollak P, Gross C, Hoffmann D, Benazzouz A, Gao DM. Acute and long-term effects of subthalamic nucleus stimulation in Parkinson's disease. Stereotact Funct Neurosurg 1994; 62: 7684. Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 1990; 249: 14368. Bevan MD, Magill PJ, Terman D, Bolam JP, Wilson CJ. Move to the rhythm: oscillations in the subthalamic nucleusexternal globus pallidus network. Trends Neurosci 2002; 25: 52531. Brotchie JM, Mitchell IJ, Sambrook MA, Crossman AR. Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate. Mov Disord 1991; 6: 1338. Bronstein JM, DeSalles A, DeLong MR. Stereotactic pallidotomy in the treatment of Parkinson disease: an expert opinion. Arch Neurol 1999; 56: 10649. Carbon M, Eidelberg D. Modulation of regional brain function by deep brain stimulation: studies with positron emission tomography. Curr Opin Neurobiol 2002; 15: 4515. Chen CC, Lee ST, Wu T, Chen CJ, Huang CC, Lu CS. Hemiballism after subthalamotomy in patients with Parkinson's disease: report of 2 cases. Mov Disord 2002; 17: 136771 and flumist.
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