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8. Quadratic Stabilization of Uncertain Discrete-time Switched Linear Systems, Ji Zhijian, Wang Long
And the relatively small sample sizes, which affect the power of the tests. RESULTS Sample characteristics Table 1 shows that most study participants were Dutch, male, of low educational level, unemployed and unmarried. In Sample A, most subjects were inpatient alcoholics 77.7% ; , whereas in Sample B 29.9% were inpatient, 41.1% were outpatient and 28.9% were currently not seeking treatment. Most subjects had moderate to severe levels of alcohol dependence. Sample A was less well educated and more severely addicted according to the AUDIT scores than Sample B. These differences seem to be related to the presence of nontreatment-seeking alcoholics in Sample B who were more highly educated P 0.01 ; and less severely addicted according to the AUDIT P 0.01 ; than the treatment-seeking alcoholics in Sample B. Factor structure and internal consistency of the AMDS sub ; scales content validity ; As a first step, the internal consistencies of the theoretical AMDS scales were calculated in Sample A. Internal consistencies of the relief and reward scales were high a 0.97 for both scales ; . Internal consistencies of the nine subscales were also good ranging from a 0.90 to a 0.95 for the relief subscales and from a 0.87 to a 0.94 for the reward subscales ; . We expected to find low correlations between relief and reward scales. However, the correlation for the relief and reward scales was 0.84 P 0.01 ; , whereas the correlations between the relief and reward subscales ranged from 0.46 to 0.83 P 0.01 ; Table 2 ; . The lowest correlations were found between the negatively formulated relief and the positively formulated reward subscales, ranging from r 0.33 P 0.01 ; for the correlation between the negatively formulated `vulnerability' subscale vul-neg ; and the positively formulated `stimulation seeking' subscale sti-pos ; to r 0.78 P 0.01 ; for the correlation between the positively formulated `dominance' subscale dom-pos ; and the negatively formulated `shyness' subscale shy-neg ; Table 3 ; . Given the generally high interscale correlations between reward and relief motives, we questioned whether the AMDS really
And gentle mechanical stimulation.61 Animal studies have confirmed that adrenergic sensitivity may develop following injury of the peripheral nerve. Electrophysiological recordings from normal DRG neurons have indicated that NE can evoke either hyperpolarization and or a small depolarization in different species.53, 74, 102, 115 However, the NE evoked depolarization is of insufficient magnitude to generate action potentials. After PNS injury, the coupling of one or more different types of adrenoceptors to ionic conductance may be significantly altered. Clonidine, an agonist that has higher affinity for 2 than 1 adrenoceptors, 33, 71 induced a greater response than NE, suggesting that the adrenergic sensitivity of nerve injured DRG neurons is mainly mediated by 2 receptors. Likewise, the excitatory effect of adrenergic agonists on DRG neurons in nerve-injured rat can be blocked by yohimbine, an 2 antagonist, but not prazosin, a selective 1 antagonist.120 The demonstration of an up-regulation of 2 adrenoceptors in small and medium sized somata of sensory neurons after a partial cut of peripheral nerve is consistent with the results obtained from electrophysiological studies.73 Recently, it was found that extensive sympathetic sprouting occurred in the DRG following PNS injury.15, 58 It is currently unclear, however, how damaged nerves develop an increased adrenergic sensitivity, or what triggers the sprouting of sympathetic nerve ending in the ganglion. The ionic mechanisms underlying the effect of NE on DRG cells are not known. However, certain studies on peripheral and central neurons indicate that NE-induced depolarization is associated with a reduction in resting potassium conductance. 31, 109, 123 It remains to be determined whether this or another mechanism contributes to NE induced activity in DRG cells after PNS injury. CENTRAL MECHANISMS OF NEUROPATHIC PAIN In some patients, the pain and or hyperalgesia resulting from a nerve injury can extend well outside the distribution of the injured nerve suggesting possible changes in sensory.
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[insert necessary information here to reflect the change in NDA ownership from Wyeth-Ayerst to Baxter Healthcare Corporation] Revised November 2003 Printed in U.S.
Premature Commitment PREM ; Premature commitment indicates the amount of decisions that programmers have to make when writing code and the consequences of those decisions, i.e. how easy is to recover from initial decisions. If an API presents users with a minimal number of choices about how to accomplish some goal and if the differences between the alternatives are minimal, the API exposes a minimal and reversible level of premature commitment. When the number of choices is significant but the differences among them are minimal, the API presents a significant and reversible level of premature commitment. In the cases in which the alternatives are abundant and the differences between them are significant, the level of premature commitment is said to be significant and irreversible. 179.
Hematopoietic stem cell transplantation HSCT ; in first complete remission has been advocated by some groups, although this approach warrants prospective validation. Subcutaneous panniculitis-like T-cell lymphoma SCPTCL ; SCPTCL is a rare T-cell lymphoma that primarily infiltrates the subcutaneous fat without dermal and epidermal involvement causing erythematous to violaceous nodules and or plaques. It is often associated with a systemic hemophagocytic syndrome; characterized by high fever, skin lesions, lung infiltrates, jaundice, hepatosplenomegaly, liver dysfunction, coagulation abnormalities, pancytopenia, and a benign prominent histiocytic proliferation with hemophagocytosis. The hemophagocytic syndrome associated with Tcell neoplasms can occur preceding, during or while the disease is in remission.80, 81 Moreover, a controversial entity known as cytophagic histiocytic panniculitis CHP ; has been described as an inflammatory disease with a possible association to SCPTCL.81 CHP is a disease that has been recognized to have diverse outcomes ranging from indolent to aggressive fatal clinical courses.82 In the recent WHO-EORTC classification, only the cases with an phenotype are classified as SCPTCL. Cases previously and goldenseal.
Received drugs with antiemetic effects e.g. phenothiazines, benzamides, scopolamine, corticosteroids and tricyclic antidepressants ; in the 24 h before surgery. Children did not consume milk or solid food for at least 6 h before operation; clear uids were allowed until 3 h before induction. We did not control the volume of uid children ingested within 3 h before surgery. Children were not premedicated. Anaesthesia was induced with halothane and nitrous oxide in oxygen via a facemask or with i.v. thiopental. After induction of anaesthesia and establishment of venous access, tracheal intubation was facilitated with 100 mg kg1 i.v. vecuronium, and anaesthesia was maintained with halothane and nitrous oxide along with 0.5 mg kg1 of i.v. meperidine. A random number generator was used to assign each child prospectively to receive dexamethasone 1 mg kg1 maximum 25 mg ; , ondansetron 100 mg kg1 maximum 4 mg ; or saline placebo. The study drugs were prepared by an anaesthetist not otherwise involved in patient care, to a xed volume of 5 ml, to maintain the double-blind nature of the study. Intraoperative i.v. uid management consisted of administration of lactated Ringer's solution sufcient to correct half of the preoperative uid decit in the rst hour, followed by maintenance uids according to body weight. At the end of the procedure, residual neuromuscular blockade was antagonized with 50 mg kg1 of neostigmine and 10 mg kg1 of glycopyrrolate and the trachea was extubated when the child was awake. The gastric contents were aspirated by suction via a tube passed before extubation. No nasogastric tube was left in situ during the procedure. After operation, all children were transported to the postanaesthesia care unit PACU ; . The anaesthetist who provided intraoperative care assessed postanaesthetic recovery using the modied Aldrete scoring system.4 Time to achieve complete recovery score 10 ; was recorded for all children. After operation, analgesia was provided when older children complained or younger children cried in pain.5 Oral ibuprofen 10 mg kg1 was given as the analgesic of rst choice, and for pain in children who had PONV in the immediate postoperative period in the PACU, ketorolac 0.5 mg kg1 i.v. was administered as the analgesic of second choice by the anaesthetist who provided intraoperative care. Intravenous uid comprised lactated Ringer's solution replacing the remaining uid decit plus maintenance uids in the recovery room. All episodes of nausea and vomiting in the rst 24 postoperative hours in the hospital during the intervals of 06 h and 624 h were evaluated using a numeric scoring system for PONV 0 no nausea or vomiting, 1 nausea but no vomiting, 2 vomiting once in 30 min or more, 3 persistent nausea 30 min ; or two or more vomits in 30 min ; by the PACU and ward nursing staff, who were aware of the nature of the study but blinded to the study drug. We did not assess nausea in very young children less than 6 yr of age ; . In older children, nausea was assessed by an observer and by self-reporting. Any child having a.
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Abbreviation as in Table 1. Data are presented as n % ; . * Epidural has increased 25 marked ; variability and decreased 5 minimal ; variability P .001, adjusted for multiple comparisons and gramicidin.
Intercorrelation data of absolute changes in hair parameter in both M3 F and F3 M transsexuals are shown in Table 3. In both groups, changes in hair growth rate and hair density correlated positively. After antiandrogen plus estrogen administration in M3 F transsexuals, hair growth declined; but.
Bogaard, Harm J., Susan R. Hopkins, Yoshiki Yamaya, Kyuichi Niizeki, Michael G. Ziegler, and Peter D. Wagner. Role of the autonomic nervous system in the reduced maximal cardiac output at altitude. J Appl Physiol 93: 271279, 2002; japplphysiol.00323.2001.--After acclimatization to high altitude, maximal exercise cardiac out put QT ; is reduced. Possible contributing factors include 1 ; blood volume depletion, 2 ; increased blood viscosity, 3 ; myocardial hypoxia, 4 ; altered autonomic nervous system ANS ; function affecting maximal heart rate HR ; , and 5 ; reduced flow demand from reduced muscle work capability. We tested the role of the ANS reduction of HR in this phenomenon in five normal subjects by separately blocking the sympathetic and parasympathetic arms of the ANS during maximal exercise after 2-wk acclimatization at 3, 800 m to alter maximal HR. We used intravenous doses of 8.0 mg of propranolol and 0.8 mg of glycopyrrolate, respectively. At altitude, peak HR was 170 6 beats min, reduced from 186 3 beats min P 0.012 ; at sea level. Propranolol further reduced peak HR to 139 2 beats min P 0.001 ; , whereas glycopyrrolate increased peak HR to sea level values, 184 3 beats min, confirming adequate dosing with each drug. In contrast, peak O2 consumption, work rate, and QT were similar at altitude under all drug treatments [peak QT 16.2 1.2 control ; , 15.5 1.3 propranolol ; , and 16.2 1.1 l min glycopyrrolate ; ]. All QT results at altitude were lower than those at sea level 20.0 1.8 l min in air ; . Therefore, this study suggests that, whereas the ANS may affect HR at alti tude, peak QT is unaffected by ANS blockade. We conclude that the effect of altered ANS function on HR is not the cause of the reduced maximal QT at altitude. altitude acclimatization; maximal exercise; autonomous nervous system; heart rate; propranolol; glycopyrrolate; oxygen uptake; acetylene uptake and granisetron.
Searle Division of Monsanto plc. Bremer Pharma ICN Alkaloida Hungary Company Limited, Tiszavasvari Rhne-Poulenc Rorer.
The most frequent causes of infectious diarrhea are viruses. The Norwalk virus is the most common culprit, but rotaviruses, enteric adenoviruses, and astroviruses star-shaped virus particles first seen on microscopy in 1975 ; can also cause diarrhea as well as a more generalized gastroenteritis that affects both the stomach and the intestines with nausea, vomiting, fever, prostration, and mild to moderately severe, watery diarrhea. The viral diarrheas are self-limiting diseases, which is fortunate because there is no specific treatment for them. Outbreaks of such viral gastroenteritis ravage cruise ships, schools, and church socials. Symptomatic relief is obtained by eating rice, bananas, applesauce, Gatorade, tea, flat Sprite or Seven Up shaken first until the fizz is gone ; . It is helpful to remember the BRAT diet: bananas, rice, applesauce, and tea and grepafloxacin.
Glycopyrrolate based treatments
Unlikely to independents correct level of glycopyrrolate few pharmacies offered for a glycopyrrolate.
ISIS participated in the Lafarge Cement UK Environmental Stakeholder Group meeting. Formerly known as Blue Circle, the cement business has now been and guaifenesin!
Within the perioperative period ie, first 30 days ; , the all stroke death rates were 10.2% in the surgical group and 5.5% in the endovascular group. Of those who experienced a hemodynamic disturbance, 16.0% had a neurological complication in the perioperative period, including all transient ischemic attack, amaurosis fugax, stroke, and stroke-related death. Only 5.9% of those who were hemodynamically stable did so. This was not statistically significant P 0.46, Fisher exact test ; Table 3.
Than the placebo group, but the difference did not reach statistical significance p Z0.08 ; . After the second exercise period, FEY, values in both the atropine and glycopyrrolate groups were greater than those in the placebo group p 0. 05 ; and did not differ significantly from predrug baseline values. At this point, FEY, and sGaw were also and guanethidine!
1. Alvarez A, Schreiber JR. Lemierre's syndrome in adolescent children: anaerobic sepsis with internal jugular vein thrombophlebitis following pharyngitis. Pediatrics. 1995; 96: 354-359. Hagelskjaer LH, Prag J, Malczynski J, Kristensen JH. Incidence and clinical epidemiology of necrobacillosis, including Lemierre's syndrome, in Denmark 19901995. Eur J Clin Microbiol Infect Dis. 1998; 17: 561-565. Golpe R, Matin B, Alonso M. Lemierre's syndrome necrobacillosis ; . Postgrad Med J. 1999; 75: 141-144. Moreno S, Garcia Altozano J, Pinilla B, et al. Lemierre's disease: postanginal bacteremia and pulmonary involvement caused by Fusobacterium necrophorum. Rev Infect Dis. 1989; 11: 319-324. Harar RP, MacDonald A, Pullen D, Ganesan S, Prior AJ. Lemierre's syndrome: are we underdiagnosing this life-threatening infection? ORL: J Otorhinolaryngol Relat Spec. 1996; 58: 178-181. Gudinchet F, Maeder P, Neveceral P, Schnyder P. Lemierre's syndrome in children: high-resolution CT and color Doppler sonography patterns. Chest. 1997; 112: 271-273. Ahkee S, Srinath L, Huang A, Raft MJ, Ramirez JA. Lemierre's syndrome: postanginal sepsis due to anaerobic oropharyngeal infection. Ann Otol Rhinol Laryngol. 1994; 103: 208-210 and glycopyrrolate.
We conducted this phase 2 study to determine whether imatinib, a potent inhibitor of the oncogenic Bcr-Abl tyrosine kinase, could induce hematologic responses in at least 30% of patients with CML in accelerated phase, when administered at well-tolerated doses defined in earlier trials.28-30 Results indicate that imatinib induced hematologic response lasting at least 4 weeks in 69% of patients, including CHR in 34% of patients, with manageable hematologic toxicity and few nonhematologic grade 3 or 4 adverse reactions. Treatment with imatinib also induced major cytogenetic responses in 24% of patients, 12-month progression-free survival in 59% of patients, and 12-month overall survival in 74% of patients. The efficacy of imatinib in this study far exceeded the planned success criteria defined in the protocol. The demographic features, disease history and baseline characteristics, and major prognostic factors of the patients enrolled in this trial appear to be consistent with those described in other studies with similar patients.3, 5-9 Notably, the criteria3, 4 used to define accelerated phase in this trial are more stringent than those of the International Bone Marrow Transplant Registry IBMTR ; 7 or Sokal8 classification systems, and patients with cytogenetic clonal evolution as a sole criterion for accelerated phase, representing a heterogeneous group with generally favorable prognosis, 32, 33 were excluded from this trial. Accordingly, the positive results observed with imatinib in this study are unlikely to be attributable to the selection of patients with favorable prognosis and guanfacine.
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