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WASHINGTON, June 4 UPI ; -- The first U.S. soldier charged with cowardice since the Vietnam War is suffering from damage to his brainstem that likely was caused by the anti-malaria drug he was given in Iraq, a military doctor has concluded. Staff Sgt. Georg-Andreas Pogany was diagnosed this week with "likely Lariam toxicity, " according to medical records from Naval Medical Center San Diego reviewed by United Press International. Pogany suffered a panic attack in Iraq last year after seeing a dead body and was charged by the Army with cowardice, an offense punishable by death and a charge not seen since the Vietnam era, which ended almost 30 years ago. The charge later was reduced to dereliction of duty. For months Pogany has been caught in legal and medical limbo, waiting for the Army to pursue charges against him and evaluate a list of mental and physical symptoms that started when he took Lariam in Iraq. Pogany's tests this week showed eye and ear abnormalities and balance problems consistent with reported side effects of the drug, the medical records state. He is one of 10 servicemembers diagnosed in the past few weeks with damage to the brainstem and vestibular, or balance, system after being given the drug while serving in Iraq or Afghanistan. His case is the most notable so far, because "panic attack" is listed as a Lariam side effect. Lariam is generically known as mefloquine; Pogany took the generic form. Nine months after first charging him with cowardice, the Army still has not told Pogany what charges he still might face, if any, said Pogany's attorney Richard Travis. During that time period, Army officials delayed Pogany's medical treatment and ignored data Travis sent the Army on mefloquine side effects, he said. Travis said Pogany's career in the Army is over. "I think this went from the realm of incompetence to the realm of being vindictive, " Travis said. Fort Carson has declined to answer questions about Pogany or mefloquine. A spokesman for the Army Special Operations Command at Fort Bragg, N.C., did not respond to a request for comment. Last summer, the Food and Drug Administration took aggressive steps to make sure patients taking mefloquine are warned in writing of the possible side effects, including anxiety, hallucinations, paranoia and suicidal thoughts. While the military is required by law to record the use of mefloquine in soldiers' medical records, none of the soldiers diagnosed at the Navy Medical Center in San Diego had the drug included in their records, according to Sen. Dianne Feinstein, D-Calif. The Army invented mefloquine. Pogany is based at Fort Carson, Colo., where he is attached to the 10th Special Forces Group. He served briefly in Iraq with Special Forces Chief Warrant Officer William Howell. Howell killed himself near Fort Carson in March after returning from Iraq. He also took mefloquine, and his wife, Laura, believes the drug is responsible for his suicide. Five Special Forces soldiers have committed suicide during the war on terrorism. According to the Army, four of the five had been taking mefloquine just prior to their suicides. The drug label lists "rare reports of suicide, " but the Food and Drug Administration says it does not know if the drug can trigger suicide. The Army has told UPI that it does not believe mefloquine can cause suicide and says there have not been serious or widespread problems with the drug. Pogany, 33, said he had just taken his third weekly pill when he suffered the attack after seeing the body.
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Architect Gair Williamson of Gair Williamson Architects in Vancouver, which has partnered with another Vancouver firm, Ankenman Marchand Architects, to reconfigure the Paris property, is blunt: "Nothing is what it seems." "It looks like it's a pretty easy job to figure out what has to happen next, but invariably, when you break into the walls and check the bearing strength of the soil, or you look at cracks in the faade and such, you start to become aware that there's a myriad of issues just to make this building safe, if nothing else." Two elements are critical to upgrading an old commercial building, Williamson said meeting modern seismic and building envelope requirements. "The biggest challenge for us is to walk away from these projects when they're.
This interview is about the anti-malarial drug mefloquine with retails as lariam ; , and how the australian defence force has approached malaria prevention.
Table 4. National Visit Estimates With COX-2 Inhibitor or NSAID Use Among Patients With Congestive Heart Failure, Liver Dysfunction, or Renal Dysfunction 1999-2002.
Kathleen's Mom Work: Producing three very individual bright children and staying married to the love of my life for 53 years. Play: Theater, golf, and swimming. I love live theater; golf gives me a mental and physical challenge and I enjoy the camaraderie; and swimming is good for my health. Sarah's Mom My mom says her most important work was raising two wonderful fun, funny, and aware young daughters, who have become friends to one another and to her in their adulthood. She says she doesn't know how to play; she needs to be with us more often. She always laughs when she is with us. She needs to loosen up! Lisa's Mom Work: I clearly remember asking my mom about her priorities when I was still a University student. She was adamant then-- as she still is today-- that although she and megace
Els answered by mousetourstravels - thu aug 2 : 39 2007 from yahoo answer search: lariam mon feb 4 : 18 2008 society: law: legal information: product liability: medical: pharmaceutical: lariam: directory directory see also: health: pharmacy: drugs and medications: m: mefloquine 4 ; susan rose - information on the dangers and possible side effects of the anti-malarial medication lariam.
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PHELPS, P.; A. D. STEELE UND D. J. MC CARTY 1972 ; : Significance of Xenon-133 clearance rate from canine and human joints. Arthritis Rheum. 15, 360-370.
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What does the military require? Mefloquine may be required for duty or deployment in areas where there is a risk of contracting malaria. The use of this anti-malarial medication will be based on the degree and length of exposure and the prevalence of drug resistant strains of the disease in the area s ; of travel and an individual's health status. Are there any side effects? You may have an upset stomach, stomach pain, nausea, vomiting, diarrhea, headache, insomnia, or lightheadedness. These effects should subside as your body adjusts to the medication. If these symptoms persist or become severe, inform your health care provider. This medication may cause dizziness or restlessness. Use caution when driving or engaging in activities requiring alertness. Call your health care provider if you develop unexplained anxiety, mood changes, depression, restlessness, or confusion. If you experience any allergic reactions such as flushing, itching, skin rash, breathing difficulties, or vision problems, stop taking the medication and contact your health care provider and memantine.
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Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 Diseases that cause photoreceptor cell degeneration afflict millions of people, yet no restorative treatment exists for these blinding disorders. Replacement of photoreceptors using retinal progenitor cells RPCs ; represents a promising therapy for photoreceptor degeneration. Two challenges encountered in a progenitor cell-based therapy are enhancing cell survival and directing the differentiation of the cells to functional photoreceptor fates. Previous studies have demonstrated the ability of polymer scaffolds to increase significantly both the survival and differentiation of RPCs. We report the microfabrication of a poly glycerol sebacate ; scaffold with superior mechanical properties for the delivery of RPCs to the subretinal space. The biocompatibility of the polymer scaffold with mouse RPCs and the effects of the scaffold on the expression of protein markers of differentiation are discussed. BIOL 77 Purification and characterization of recombinant 2- 2'hydroxyphenyl ; benzenesulfinate desulfinase from nocardia asteroides a3h1 Linette M Watkins, Department of Chemistry and Biochemistry, Texas State University-San Marcos, 601 University Dr, San Marcos, TX 78666, Fax: 512-2452374, linette txstate The enzyme, 2- 2'-hydroxyphenyl ; benzenesulfinate desulfinase HPBS desulfinase ; enzyme catalyzes the cleavage of the aromatic carbon-sulfur bond of 2- 2'-hydroxyphenyl ; benzenesulfinate HPBS ; to form hydroxybiphenyl and sulfite. HPBS desulfinase is the final and rate limiting enzyme in the desulfurization of the dibenzothiophene, an organosulfur contaminant in fossils fuels. The HPBS desulfinase gene from Nocardia asteroides A3H1 was cloned into a pGEX vector and soluble protein was obtained by coexpression with GroEL. Spectrofluorimetric assays were carried out to characterize the recombinant HPBS desulfinase. The characterization included measuring kinetic parameters, testing the effects of varying pH and temperature on the enzyme, and measuring the effects of metals and inhibitors. The parameters of the recombinant enzyme are similar to those of the native enzyme purified from Rhodococcus erythropolis strain sp. IGTS8. Solvent isotope studies, chemical modification studies and site directed mutagenesis experiments support the previously proposed chemical mechanism for this novel enzyme. BIOL 78 and meperidine.
Send reprint requests to: Dr. B.C. Sallustio, Department of Clinical Pharmacology, The Queen Elizabeth Hospital, 28 Woodville Rd. Woodville South 5011, South Australia.
Erick Hung University of California, San Francisco Student Representative, WMS Board of Directors Hello everyone! I have just returned from an incredible two months in Nepal. I joined Dr. Luanne Freer who has headed up the first-ever and hugely successful ; medical clinic at the base camp of Mount Everest. The Himalayan Rescue Association HRA ; , a non-profit organization that runs several high-altitude clinics in Nepal, ran the Everest Base Camp clinic. During the climbing season from April to May, we treated climbers, sherpas, and and mephenytoin.
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