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Surveillance of influenza-associated pediatric deaths will serve to complement the current national influenza surveillance strategies. By including this element in the national reporting system, basic population-based epidemiologic characteristics, such as incidence, age and geographic distribution can be determined. The collection of selected clinical information could potentially describe uncommon or previously unrecognized presentations, possible risk factors, and the impact of influenza vaccination. Linkage of mortality data with virologic and other laboratory data may provide information on strain virulence and abnormal host responses, and may guide vaccine strain selection. Coordination: Agencies for Response: 1 ; Julie L. Gerberding Director, Centers for Disease Control and Prevention 1600 Clifton Road, NE, Mailstop D-14 Atlanta, GA 30333 Telephone: 404 ; 639-7000 Email: JGerberding cdc.gov Agencies for Information: 1 ; Paul Jarris, MD, MBA Executive Director Association of State and Territorial Health Officers 2231 Crystal Drive Suite 450 Arlington, VA 22202 Phone: 202 ; 371-9090 Fax: 571 ; 527-3189 pjarris astho 2 ; Scott Becker Executive Director Association of Public Health Laboratories 8515 Georgia Avenue, Suite 700 Silver Spring, MD 20910 Telephone: 240-485-2745 ext 201 Fax: 240-485-2700: sbecker aphl.
Pediatric use nelfinavir was studied in one open-label, uncontrolled trial in 38 pediatric patients ranging in age from 2 to 13 years.
The illustrations to this article. That small doses of x rays without sub sequent changes in the skin can result in carcinoma of underlying origin has been shown in recent work on carcinoma of the thyroid. Thus I feel that a study confined.
Reflected in the April 5 laboratory test results Exhibit C-5 at medical record excerpt p. 384 ., it would not have been inappropriate to temporarily discontinue the medication until the liver function levels returned to normal range as statin therapy Lipitor ; generally is contraindicated under those conditions." Ex. B at 6. Defendant Solorzano also states in his affidavit that.
Analyzing the incidence of breast cancer and other possible side effects they might have experienced. It is important for us to state that, in a pilot study of the first 100 women who were on estrogen-androgen therapy for more than 5 years, the incidence of breast cancer in those patients was lower than that in those who were on estrogen or estrogen-progestin. The addition of androgen to the estrogen or estrogen-progestin regimen is here to stay. Judicious evaluation and use is advocated. Morrie M. Gelfand, CM, MD McGill University, Montreal, Quebec, Canada.
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October week 2 2004 ; and CINAHL 1982 to October week 2 2004 ; . The Journal of Wound Care Volume 12 13 Issues 1-10 ; was hand-searched. Manufacturers, researchers and local and international wound groups were contacted in order to identify unpublished trials. Web sites for wound groups and World Wide Wounds worldwidewounds ; were searched. Selection criteria: Randomised controlled trials and non-randomised controlled clinical trials were considered for inclusion. Studies were included if they involved participants with Type 1 or Type 2 diabetes and related foot ulcers, met the requirements for randomisation, allocation and concealment where appropriate, and compared the intervention with a placebo or a sham dressing, an alternative non silver based dressing or no dressing, and reported outcomes that represent healing rate or infection. Data collection & analysis: Two authors independently evaluated the papers identified by the search strategy against the inclusion criteria but identified no trials eligible for inclusion in the review. It was not possible to perform planned subgroup and sensitivity analysis in the absence of data. In future, if eligible trials become available, a random effects model will be applied for meta-analysis in the presence of statistical heterogeneity estimated using the I2 statistic ; . Dichotomous outcomes will be reported as risk ratios with 95% confidence intervals CI ; , and continuous outcomes as weighted mean differences WMD ; with 95% CI. Statistical significance will be set at P value 0.05 for all outcomes and the magnitude of the effect will be estimated by calculating the number needed to treat NNT ; with 95% CI. Main results: No studies were identified that met with the inclusion criteria Reviewers' conclusions: Despite the widespread use of dressings and topical agents containing silver for the treatment of diabetic foot ulcers, no randomised trials or controlled clinical trials exist that evaluate their clinical effectiveness. Trials are needed to determine clinical and cost-effectiveness and long term outcomes including adverse events.
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Coronary artery disease are displayed in Fig 5 for varying numbers of adjacent abnormal chords. In the present study, the optimal number appeared to be four or more adjacent chords.
Excreted in human breast milk is unknown; therefore, bevacizumab should not be used in women not employing adequate contraception and only if the potential benefit justifies the potential risk to the fetus. Women should be advised to discontinue nursing during treatment with bevacizumab. The safety and effectiveness of bevacizumab in pediatric patients have not been studied. Analyses of demographic data suggest that no dose adjustments are necessary for age or sex. Patient education: Patients should receive education about bevacizumab's mechanism of action, treatment regimen, potential infusion reactions and side effects of chemotherapy, and when to call for medical assistance and pegvisomant.
Through 48 weeks of therapy, the median increases from baseline in CD4 + cell counts were 81 cells mm3 with twice-daily LEXIVA ritonavir and 91 cells mm3 with lopinavir ritonavir. This study was not large enough to reach a definitive conclusion that LEXIVA ritonavir and lopinavir ritonavir are clinically equivalent. Once-daily administration of LEXIVA plus ritonavir is not recommended for protease inhibitor-experienced patients. Through Week 48, 50% and 37% of patients receiving LEXIVA 1, 400 mg plus ritonavir 200 mg once daily had plasma HIV-1 RNA 400 copies mL and 50 copies mL, respectively. 14.3 Pediatric Patients Two open-label studies in pediatric patients 2 to 18 years of age were conducted. In one study, twice-daily dosing regimens LEXIVA with or without ritonavir ; were evaluated in combination with other antiretroviral agents. A second study evaluated once-daily dosing of LEXIVA with ritonavir; the data from this study were insufficient to support a once-daily dosing regimen in any pediatric patient population. LEXIVA: Eighteen 16 therapy-naive and 2 therapy-experienced ; pediatric patients received LEXIVA Oral Suspension without ritonavir twice daily. At Week 24, 67% 12 ; achieved HIV-1 RNA 400 copies mL, and the median increase from baseline in CD4 + cell count was 353 cells mm3. LEXIVA plus ritonavir: Twenty-seven protease inhibitor-naive and 30 protease inhibitor-experienced pediatric patients received LEXIVA Oral Suspension or Tablets with ritonavir twice daily. At Week 24, 70% of protease inhibitor-naive 19 27 ; and 57% of protease inhibitor-experienced 17 30 ; patients achieved HIV-1 RNA 400 copies mL; median increases from baseline in CD4 + cell counts were 131 cells mm3 and 149 cells mm3 in protease inhibitor-naive and experienced patients, respectively. HOW SUPPLIED STORAGE AND HANDLING LEXIVA Tablets, 700 mg, are pink, film-coated, capsule-shaped, biconvex tablets, with "GX LL7" debossed on one face. Bottle of 60 with child-resistant closure NDC 0173-0721-00 ; . Store at controlled room temperature of 25C 77F excursions permitted to 15 to 30C 59 to 86F ; see USP Controlled Room Temperature ; . Keep container tightly closed. LEXIVA Oral Suspension, a white to off-white suspension, contains 50 mg of fosamprenavir as fosamprenavir calcium equivalent to approximately 43 mg of amprenavir in each 1 mL. Bottle of 225 mL with child-resistant closure NDC 0173-0727-00 ; . This product does not require reconstitution. Store at 5 to 30C 41 to 86F ; . Shake vigorously before using. Do not freeze. 17 PATIENT COUNSELING INFORMATION See FDA-approved Patient Labeling 17.6 ; 17.1 Drug Interactions 38 16.
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Conclude that the pharmacokinetics of amikacin in patients with hematologic malignancies including one with aplastic anemia ; are different from previous reports for healthy adults. Pharmacokinetic studies of amikacin have also been performed with eight pediatric oncology patients who received 5 mg of the drug per kg every 6 to 8 The elimination half-life averaged 1.2 h, volume of distribution averaged 0.24 liters kg, and total body clearance averaged 2.51 ml min per kg. The volume of distribution and the clearance are greater than values reported for other pediatric groups and probably account for the larger dose per kilogram ; needed to achieve and maintain therapeutic levels in these patients 7 ; . In another retrospective review of pharmacokinetic data obtained from 35 aminoglycoside regimens given to 32 hospitalized oncology-hematology patients, the volume of distribution mean standard deviation ; for all aminoglycosides was 0.41 + 0.31 liters kg, with a range of 0.20 to 0.65 liters kg, values much larger than previously reported for nononcology patients 9 ; . The need to increase the dose of amikacin in patients with hematologic-oncologic conditions was emphasized in both these studies. Overall, our data for adults are consistent with results of previous studies in pediatric patients. The mechanism of increase of volume of distribution and total body clearance of amikacin in hematologic patients is unclear. We attempted to correlate physiological characteristics of the patients such as creatinine clearance, hemoglobin, temperature, and serum albumin to pharmacokinetic parameters such as volume of distribution and total body clearance. However, multiple stepwise regression analyses did not reveal any significant relationship. This may be because the data were insufficient to establish significant and pemetrexed.
Prevalence and risk of heart failure and diabetes. This study is intended to provide information about the balance of risks and benefits relevant to recommendations for use of these agents
A. flavus has been particularly prevalent in the air of some tropical countries Moubasher et al., 1981; Abdalla, 1988; Gupta et al., 1993; Adhikari et al., 2004 ; . Climatic conditions markedly influence the prevalence of A. flavus in outdoor air. As an example, two Spanish studies revealed very different results. In Barcelona A. flavus and A. niger were the most frequent airborne aspergilli Calvo et al., 1980 ; whereas in Madrid A. fumigatus was the most prevalent species 54 % ; Guinea et al., 2005 ; . Comparing Aspergillus species in the air in London, Paris, Lyon and Marseille, Mallea et al. 1972 ; showed that A. glaucus and A. versicolor group predominated in southern France. On the other hand, A. fumigatus represented more than 35 % of the isolates recovered from Paris and London, whereas A. glaucus group never exceeded 20 % Mallea et al., 1972 ; . In Brussels, A. fumigatus was the most common Aspergillus species whereas A. flavus represented only 1 % of isolates Vanbreuseghem & Nolard, 1985 and pemoline.
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33. Sinus and Allergy Health Partnership. 2000 ; . Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngology Head and Neck Surgery 123, 531. 34. Dowell, S. F., Marcy, S. M., Phillips, W. R., Gerber, M. A. & Schwartz, B. 1998 ; . Otitis media principles of judicious use of antimicrobial agents. Pediatrics 101, 16571. 35. Bartlett, J. G., Bradley, S. F., Herwaldt, L. A., Jacobs, M. R., Perl, T. M., Poole, M. D. et al. 1999 ; . A roundtable discussion of antibiotic resistance: putting the lessons to work. Amercian Journal of Medicine 106, 48S52S. 36. Orr, P. H., Scherer, K., MacDonald, A. & Moffat, M. E. K. 1993 ; . Randomised placebo-controlled trials of antibiotics for acute bronchitis: a critical review of the literature. Journal of Family Practice 36, 50712. 37. Ball, P. & Make, B. 1998 ; . Acute exacerbations of chronic bronchitis: an international comparison. Chest 113, Suppl. 3, 199S 204S. Fine, M. J., Smith, M. A., Carson, C. A., Meffe, F., Sankey, S. S., Weissfeld, L. A. et al. 1994 ; . Efficacy of pneumococcal vaccination in adults: a meta-analysis of randomised controlled trials. Archives of Internal Medicine 154, 266677. 39. Douglas, R. G. Jr 1990 ; . Prophylaxis and treatment of influenza. New England Journal of Medicine 322, 44350. 40. Nichol, K. L., Margolis, K. L., Wuorenma, J. & Von Steinberg, T. 1994 ; . The efficacy and cost-effectiveness of vaccination against influenza among elderly persons living in the community. New England Journal of Medicine 331, 77884. 41. Christenson, B., Lunbergh, P., Hedlund, J. & Ortqvist, A. 2001 ; . Effects of a large scale intervention with influenza and 23-valent pneumococcal vaccines in adults aged 65 years or older: a prospective study. Lancet 357, 100811. 42. Dagan, R., Klugman, K. P., Craig, W. A. & Baquero, F. 2001 ; . Evidence to support the rationale that bacterial eradication in respiratory tract infection provides guidance for antimicrobial therapy. Journal of Antimicrobial Chemotherapy 47, 12940. 43. Marchant, C. D., Carlin, S. A., Johnson, C. E. & Shurin, P. A. 1992 ; . Measuring the comparative efficacy of antibacterial agents for acute otitis media: the `Polyanna phenomenon'. Journal of Pediatrics 120, 727. 44. Pechre, J. C. 1998 ; . Modeling and predicting clinical outcomes of antibiotic therapy. Infectious Medicine 15, Suppl. E, 4654. 45. Destache, C. J., Dewan, N., O'Donohue, W. J., Campbell, C. J. & Angelillo, V. A. 1999 ; . Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis. Journal of Antimicrobial Chemotherapy 43, Suppl. A, 10713. 46. Weiss, K., Restieri, C., Gauthier, R., Laverdire, M., McGeer, A., Davidson, R. J. et al. 2001 ; . A nosocomial outbreak of fluoroquinolone-resistant Streptococcus pneumoniae. Clinical Infectious Diseases 33, 51722. 47. Ball, P., Wilson, R., Mandell, L., File, T., Kirsch, J. & the GLOBE Study Group. 2000 ; . Gemifloxacin long-term exacerbations in bronchitis exacerbations GLOBE ; study an assessment of health outcome benefits in AECB patients following 5 days of gemifloxacin therapy. In Program and Abstracts of the Fortieth Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, 2000. Abstract 812, p. 475. American Society for Microbiology, Washington, DC. 48. Andes, D. 2001 ; . Pharmacokinetic and pharmacodynamic properties of antimicrobials in the therapy of respiratory tract infections. Current Opinion in Infectious Disease 14, 16572. 49. Craig, W. A. 1998 ; . Pharmacokinetic pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clinical Infectious Diseases 26, 112. 50. Craig, W. A. & Andes, D. R. 1996 ; . Pharmacokinetics and pharmacodynamics of antibiotics in otitis media. Pediatric Infectious Disease Journal 15, 2559. 51. Drusano, G. L. & Craig, W. A. 1997 ; . Relevance of pharmacokinetics and pharmacodynamics in the selection of antibiotics for respiratory tract infections. Journal of Chemotherapy 9, Suppl. 3, 3844. 52. Preston, S. L., Drusano, G. L., Berman, A. L., Fowler, C. L., Chow, A. T., Dornseif, B. et al. 1998 ; . Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials. Journal of the American Medical Association 279, 1259. 53. Forrest, A., Nix, D. E., Ballow, C. H., Goss, T. F., Birmingham, M. & Schentag, J. J. 1993 ; . Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrobial Agents and Chemotherapy 37, 107381. 54. Highet, V. S., Forrest, A., Ballow, C. H. & Schentag, J. J. 1999 ; . Antibiotic dosing issues in lower respiratory tract infection: population-derived area under inhibitory curve is predictive of efficacy. Journal of Antimicrobial Chemotherapy 43, Suppl. A, 5563. 55. Schentag, J. J., Nix, D. E., Forrest, A. & Adelman, M. H. 1996 ; . AUIC the universal parameter within the constraint of a reasonable dosing interval. Annals of Pharmacotherapy 30, 102931. 56. Thomas, J. K., Forrest, A., Bhavnani, S. M., Hyatt, J. M., Cheng, A. & Ballow, C. H. 1998 ; . Pharmacodynamic evaluation of factors associated with the development of bacterial resistance in acutely ill patients during therapy. Antimicrobial Agents and Chemotherapy 42, 5217. 57. Wright, D. H., Brown, G. H., Peterson, M. L. & Rotschafer, J. C. 2000 ; . Application of fluoroquinolone pharmacodynamics. Journal of Antimicrobial Chemotherapy 46, 66984. 58. Woodnutt, G. 2000 ; . Pharmacodynamics to combat resistance. Journal of Antimicrobial Chemotherapy 46, Topic T1, 2531. 59. Bax, R., Gabbay, F., Phillips, I. & the Witley Park Study Group. 1999 ; . Antibiotic clinical trials the Witley Park Symposium. Clinical Microbiology and Infection 5, 77488. 60. Woodnutt, G. & Berry, V. 1999 ; . Efficacy of high-dose amoxicillinclavulanate against experimental respiratory tract infections caused by strains of Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 43, 3540. 61. Cenjor, C., Ponte, C., Parra, A., Nieto, E., Garcia-Calvo, G., Gimenez, M. J. et al. 1998 ; . In vivo efficacies of amoxicillin and cefuroxime against penicillin-resistant Streptococcus pneumoniae in a gerbil model of acute otitis media. Antimicrobial Agents and Chemotherapy 42, 13614. 62. Berry, V., Page, R., Satterfield, J., Singley, C., Straub, R. & Woodnutt, G. 1999 ; . Comparative efficacy of gemifloxacin SB-265805 ; against experimental respiratory tract infection in rats caused by ciprofloxacin-resistant strains of Streptococcus pneumoniae and Haemophilus influenzae. In Program and Abstracts of the Thirty-ninth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, 1999. Abstract 1548, p. 76. American Society for Microbiology, Washington, DC.
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There are also parallels between Indian philosophy and contemporary marketing theory, which has shifted away from manipulating consumers to collaborating with them. "Marketing has tended to use the language of conquest, " says Kellogg professor Mohanbir S. Sawhney, a Sikh who discusses the relevance of the Bhagavad Gita to business on his Web site. Now the focus is on using customer input to dream up new products, Sawhney says, which "requires a symbiotic relationship with those around us." Kellogg's Jain, who is working on a book about the customer-centric business models of Indian companies, believes that many Indian thinkers are drawn to fields stressing interconnectedness for good reason. "We have picked areas that are consistent with our passion, " he says.Whatever the common themes, India, of course, is hardly a showcase of social consciousness. While companies such as Tata Group or Wipro Technologies have generous initiatives for India's poor, the country has its share of unethical business practices and social injustices.In addition, some Indian academics bristle at the suggestion that their background makes their approach to business any different. They're quick to point out the wide range of religions, influences, and specialties among them.Indeed, it's not surprising that thinkers from a country with as diverse an economic and social makeup as India would have different perspectives on the influences on their work. "We are a fusion society, " says Harvard's Khurana.As a result, many Indian management theorists "tend to look at organizations as complex social systems, where culture and reciprocity are important, " he says. "You won't hear too many of us say the only legitimate stakeholders in a company are stockholders."What's more, India's extreme poverty imposes a natural pressure on its companies to contribute more to the common good. Indian thinkers influencing US firms Indian thinkers are affecting not only the way managers run companies. They are also furthering their search for personal fulfillment. Northwestern's Kellogg even offers an executive education leadership course by Deepak Chopra, the controversial self-help guru and spiritual healer to the stars.Chopra also is on the board of clothing retailer Men's Wearhouse Inc. and has conducted programs for Deloitte, Harvard Business School, and the World Bank.In a stark, brightly lit classroom, Chopra, sporting glasses with heavy black frames studded with rhinestones, led a class through a 20-minute meditation in June. "Sit comfortably in your chair with your feet planted on the ground, " Chopra instructed the 35 mostly midlevel executives from corporations that are as far afield as ABN Amro Bank and sporting goods retailer Cabela's Inc. "Our mantra today is: I am.'"Other B-schools are adding courses that combine ancient wisdom with the needs of modern managers. A popular class at both Columbia Business School and London Business School is "Creativity & Personal Mastery, " taught by Columbia's Srikumar Rao.Many attendees are fast-track managers who are highly successful at work but still miserable, says Rao. His lectures, which include mental exercises and quotes from Indian swamis and other philosophers, win praise from managers such as Goldman Sachs Group Inc. Managing Director Mark R. Tercek. "Business schools ought to be championing this stuff, " says Tercek, a yoga practitioner. "We can hire the smartest damn people in the world, but many of them ultimately don't succeed because they can't motivate and work with those around them. I think the Indians are on to something." India's biggest impact They may be on to quite a lot. Some Indian theorists have said their ultimate goal is to promote an entirely different theory of management -- one that would replace shareholder capitalism with stakeholder capitalism.The late Sumantra Ghoshal was attempting to do just that. At the time he died, the prolific London Business School professor was working on a book to be called A Good Theory of Management.As Ghoshal saw it, the corporate debacles of a few years ago were the inevitable outgrowth of theories developed by economists and absorbed at business schools. Corporations are not merely profit machines reacting to market forces; they are run by and for humans, and have a symbiotic relationship with the and penicillamine.
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Researchers studying kidney cancer are using the new Small Animal Imaging Program SAIP ; on campus to help develop a mouse model that could be used to test potential new treatments. Once the model is developed, the group, led by Laura Schmidt, Ph.D., SAIC-Frederick, Inc., could administer a new drug and then use the facility's clinical-grade MRI to see if the treatment is effective, without having to sacrifice the animal. "We could follow the therapeutic treatment in the living animal and follow it long-term, " Dr. Schmidt said. Her group, which supports the Urologic Oncology Branch, Center for Cancer Research CCR ; , has already produced a mouse model for Birt-HoggDub syndrome, a genetic disorder that increases the risk of kidney cancer. They are currently using the imaging facility to study the progression of a polycystic kidney phenotype in this mouse model and to assess the effectiveness of potential treatments in the live animals. The Laboratory of Cancer Prevention is interested in using the facility to visualize the early stages of tumor growth in the colon using MRI, ultrasound, and other imaging modalities. These tumorigenesis studies could reveal potential new targets for early intervention. The Nanotechnology Characterization Laboratory NCL ; , established by NCI's Office of Technology and Industrial Relations OTIR ; and operated by SAIC-Frederick, Inc., has used the new facility to track the biodistribution and half-life of nanoparticles in vivo. This work will pave the way for using nanotechnology and pennyroyal.
MALT lymphoma is the third most common type of non-Hodgkin lymphoma, although it only accounts for about 7-8% of these tumours. MALT lymphomas have been described at almost all extra-nodal sites, but are most commonly found in the gastrointestinal tract stomach is the commonest ; . Low grade gastric MALT tumours which are associated Helicobacter Pylori infection respond in over 80% of cases to helicobacter eradication. A proportion of patients will not respond to eradication therapy alone and will go on to more conventional antilymphoma therapies such as such as cyclophosphamide, chlorambucil, nucleoside analogues, or radiotherapy. PANCREATITIS Coxsackie, mumps, ECHO and hepatitis viruses as well as hypothermia can cause acute pancreatitis. The following are poor prognostic indicators in acute pancreatitis: Calcium 2.0 hypocalcaemia rather than hypercalcaemia as a consequence ; WCC 15 Urea 16 ALT 200 PaO2 8 Age 55 years Glucose 10 Chronic Pancreatitis Cullen's sign periumbilical discolouration ; can be present Grey Turner's sign flank discoloration ; can be present Purtscher's retinopathy ischaemic areas in the retina ; can be present lack of digestive enzymes leads to steatorrhoea In chronic pancreatitis, trypsin secretion is reduced. Trypsin is required in the processing of dietary B12 which enables absorption and hence B12 deficiency is the most likely. Causes of a raised amylase are: acute chronic pancreatitis pancreatic cysts and carcinoma perforated duodenal ulcer ovarian carcinoma ectopic pregnancy gallstones salivary tumour adenitis mumps diabetic ketoacidosis anorexia.
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Midazolam and diazepam for endoscopic sedation in children, Dev Pharmacol Ther. 1990; 14: 141-147 Hawk W, Crockett RK, Ochsenschlager DW, Klein BL. Conscious sedation of the pediatric patient for suturing: a survey. Pediatr Emerg Care, 1990; 6: 84-88 Jaffe RB, Sedation and imaging protocol. Semin Ultrasound CT MR. 1990; 1 Kato 5, Nakagawa H, Harada Y, et al. A clinical study of upper gastrointestinal endoscopy in Japanese children. Acta Paediatr Jpn. 1991; 33: 36-42 . Und U, Mushlin PS, Sedation, analgesia, and anesthesia for radiologic procedures. Cardiovasc Jnteruent Radio!, 1987; 10: 247-253 Guidelines for the use of anesthetic agents which alter the states of consciousness. NY State Dent J. 1987; 53: 17-18 and pentamidine.
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8. Cranston JW, Yoast R. Abuse of dextromethorphan. Arch Fam Med. 1999; 8: 99 Boyer EW. Dextromethorphan abuse. Pediatr Emerg Care. 2004; 20: 858 Miller SC. Coricidin HBP cough and cold addiction. J Acad Child Adolesc Psychiatry. 2005; 44: 509 Schwartz RH. Adolescent abuse of dextromethorphan. Clin Pediatr Phila ; . 2005; 44: 565568 Falck RS, Wang J, Carlson RG, Siegal HA. Variability in drug use prevalence across school districts in the same locale in Ohio. J Sch Health. 2002; 72: 288 Carr BC. Efficacy, abuse, and toxicity of over-the-counter cough and cold medicines in the pediatric population. Curr Opin Pediatr. 2006; 18: 184 and pentasa.
Results The mean time to re-evaluation was 36 months range: 1293 months ; . No statistically significant relationship was found between the time to re-evaluation and sperm concentration, when the follow-up period was 12 months. Therefore, we did not subdivide the patients into subgroups by length of follow-up period. Patient distribution by sperm concentration before and after treatment is shown in Table I. Since we dealt with patients referred for sperm cryopreservation, none of those who entered the study was azoospermic before treatment; however, at the time of follow-up 11 patients 33.3% ; had become azoospermic after treatment. Serum testosterone and FSH concentrations prior to treatment were not predictive of the change in sperm concentration P 0.05 ; . There was no statistically significant difference between HD and NHL patients regarding improvement or deterioration in sperm concentration Table II ; . Most of the patients with localized disease stages I or II ; preserved their initial sperm concentration, while deterioration in sperm concentration was detected in patients with widespread disease stages III or IV ; P 0.016 ; , as shown in Table II. No.
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