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8, 2002 amgen to acquire filgrastim and pegfilgrastim in europe from roche thousand oaks, ca, usa and basel, switzerland - may 7, 2002 - roche and amgen nasdaq: amgn ; , announced today that amgen has purchased from roche the assets and business related to filgrastim and pegfilgrastim in the european union, switzerland and norway.
Substances classified under c ; of each item: liquids: solids: not more than 3 litres per inner packaging and not more than 12 litres per package; not more than 6 kg per inner packaging and not more than 24 kg per package.
33. Gradishar WJ, Tjulandin S, Davidson N, et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol. 2005; 23: 7794-7803. Pegram M, Hsu S, Lewis G, et al. Inhibitory effects of combinations of HER-2 neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene. 1999; 18: 2241-2251. Forbes JF, Kennedy J, Piendowski T, et al. BCIRG 007: randomized phase III trial of trastuzumab plus docetaxel with or without carboplatin first line in HER2 positive metastatic breast cancer MBC ; : main time to progression TTP ; analysis. Oral presentation at: American Society of Clinical Oncology Annual Meeting; June 2-6, 2006; Atlanta, Ga. Abstract LBA516. 36. Leonard R, O'Shaughnessy J, Vukelja S, et al. Detailed analysis of a randomized phase III trial: can the tolerability of capecitabine plus docetaxel be improved without compromising its survival advantage? Ann Oncol. 2006; 17: 1379-1385. Albain KS, Nag S, Calderillo-Ruiz G, et al. Global phase III study of gemcitabine plus paclitaxel GT ; vs. paclitaxel T ; as frontline therapy for metastatic breast cancer MBC ; : first report of overall survival. J Clin Oncol. 2004; 22 suppl 14S ; : 5. Abstract 510. 38. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology: Cancer- and Treatment-Related Anemia. Version 2.2006. Available at: : nccn professionals physician gls PDF anemia . Accessed October 17, 2006. 39. Lyman GH, McMahon B, Kuderer NM, et al. A risk model for chemotherapy-induced anemia CIA ; in cancer patients. Blood. 2005; 106. Abstract 754. 40. Shayne M, Culakova E, Wolff D, et al, for the ANC Study Group. A prospective assessment of variables contributing to reduced relative dose intensity in patients with early-stage breast cancer receiving adjuvant chemotherapy. Oral presentation at: San Antonio Breast Cancer Symposium; December 8-11, 2005; San Antonio, Tex. Abstract 2075. 41. Lyman GH, Dale DC, Crawford J. Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices. J Clin Oncol. 2003; 21: 4524-4531. Budman DR, Berry DA, Cirrincione CT, et al, for the Cancer and Leukemia Group B. Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. J Natl Cancer Inst. 1998; 90: 1205-1211. Kuderer NM, Crawford J, Dale DC, Lyman GH. Meta-analysis of prophylactic granulocyte colony-stimulating factor G-CSF ; in cancer patients receiving chemotherapy. Oral presentation at: American Society of Clinical Oncology Annual Meeting; May 13-17, 2005; Orlando, Fla. 44. Vogel CL, Wojtukiewicz MZ, Carroll RR, et al. First and subsequent cycle use of pegfilgrastim prevents febrile neutropenia in patients with breast cancer: a multicenter, double-blind, placebocontrolled phase III study. J Clin Oncol. 2005; 23: 1178-1184. Rader ME, Breyer W, Luedke S, et al. First and subsequent cycle pegfilgrastim results in low rates of neutropenic events in patients receiving myelosuppressive chemotherapy. Presented at: San Antonio Breast Cancer Symposium; December 8-11, 2005; San Antonio, Tex. Abstract 5031. 46. Henderson IC, Berry DA, Demetri GD, et al. Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J Clin Oncol. 2003; 21: 976-983. Burstein HJ, Parker LM, Keshaviah A, et al. Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic support for dosedense every-2-week adjuvant breast cancer chemotherapy. J Clin Oncol. 2005; 23: 8340-8347. Smith TJ, Khatcheressian J, Lyman GH, et al. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol. 2006; 24: 3187-3205. Neupogen filgrastim ; [package insert]. Thousand Oaks, Calif: Amgen Inc; 2004. 50. Neulasta pegfilgrastim ; [package insert]. Thousand Oaks, Calif: Amgen Inc; 2005.
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Demographic characteristics of the first cycle sample are shown in Table 1. Patients were predominantly female, Caucasian, and married, with 85% having a high-school diploma or higher education. Breast 52% ; and lung cancers 26% ; were the predominant types of cancer. Breast cancer was predominantly stages I and II, whereas gastrointestinal, genitourinary, gynecologic, head and neck, and lung cancers were predominantly stages III and IV. The most frequently represented treatment used across many types of cancer was cisplatin and carboplatin 39% ; , followed by 5-FU, doxorubicin, and cyclophosphamide 18% ; , which was used exclusively in breast cancer. In the first cycle, a total of 23 patients received treatment of neutropenia filgrastim [Neupogen; n 17], pegfilgrastim [Neulasta; n 4], or sargramostim [Leukine, Prokine; n 2] ; , and treatment was initiated in most patients at either grade 3 or 4 neutropenia. Table 2 shows the frequency of different neutropenia treatments by chemotherapy regimen and day of administration of the respective neutropenia treatment within the first cycle. There were only two cases of FN, neither of which required hospitalization; they are noted in Table 2.
Bannerji, R., Kitada, S., Flinn, I. W., Pearson, M., Young, D., Reed, J. C., et al. 2003. Apoptotic-regulatory and complementprotecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. J. Clin. Oncol. 21: 14661471. Farag, S. S., Flinn, I. W., Modali, R., Lehman, T. A., Young, D., & Byrd, J. C. 2004. Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia. Blood. 103: 1472-1474. Huff, C. A., Fuchs, E. J., Noga, S. J., O'Donnell, P. V., Ambinder, R. F., Diehl, L., et al. 2003. Long-term follow-up of T cell depleted allogeneic bone marrow transplantation in refractory multiple myeloma: importance of allogeneic T cells. Biol. Blood Marrow Transplant. 9: 312-319. Malek, S. N., & Flinn, I. W. 2003. Incorporating monoclonal antibodies in blood and marrow transplantation. Semin. Oncol. 30: 520-530. Malek, S. N., Hatfield, A. J., & Flinn, I. W. 2003. MALT lymphomas. Curr. Treat. Options Oncol. 4: 269-279. Vose, J. M., Crump, M., Lazarus, H., Emmanouilides, C., Schenkein, D., Moore, J., et al. 2003. Randomized, multicenter, openlabel study of pegfilgrastim compared with daily filgrastim after chemotherapy for lymphoma. J. Clin. Oncol. 21: 514-519.
And the skin only, in a very limited space. Nothing proves more strongly the faculty, which the gymnotus possesses, of darting and directing its stroke at will, than the observations made at Philadelphia and Stockholm, * on gymnoti rendered extremely tame. * By MM. Williamson and Fahlberg. The following account is given by the latter gentleman. "The gymnotus sent from Surinam to M. Norderling, at Stockholm, lived more than four months in a state of perfect health. It was twenty-seven inches long; and the shocks it gave were so violent, especially in the open air, that I found scarcely any means of protecting myself by non-conductors, in transporting the fish from one place to another. Its stomach being very small, it ate little at a time, but fed often. It approached living fish, first sending them from afar a shock, the energy of which was proportionate to the size of the prey. The gymnotus seldom failed in its aim; one single stroke was almost always sufficient to overcome the resistance which the strata of water, more or less thick according to the distance, opposed to the electrical current. When very much pressed by and pegvisomant.
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J clin oncol -100, 1999 siena s, piccart mj, holmes fa, et al: a combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily filgrastim in patients with stage ii-iv breast cancer
Endocrine and hormonal disorders signify an indirect cause of erection disorders. A low concentration of the male sex hormone testosterone causes a diminished libido, i.e. a lesser amount of sexual desire. A too high production of prolactin by the hypophysis, a small gland near the brain, may add to a low testosterone production and, thus, cause a lower libido. Diabetes may also be considered an endocrine disorder. Medication may also cause erection problems as an side effect. More than 200 different types of medication fall into this category. Patients should however never change the dose of the medication on their own without consulting their physician; the medication is always prescribed for a reason, so changing the dose may prove hazardous. Drug and other abusive use, like drinking alcohol or smoking may damage the nerves and bloodvessels needed for a normal erection and pemetrexed.
If you are giving pegfilgrastim to yourself, your doctor or health care professional will instruct you on how to use pegfilgrastim properly.
WHP requires that physicians obtain approval before prescribing certain medications. This process helps to make sure that medications are prescribed using well-established medical guidelines. If a member does not fit the criteria that are established for each medication, WHP will work with the physician to find a suitable alternative. COVERED SERVICES UNDER PHARMACY BENEFIT Brand Name Generic Name Class Indication Aciphex * Rabeprazole PPI Actimmune Interferon Gamma-1B Biotech Avastin Bevacizumab Oncology Allegra, Allegra-D Fexofenadine Allergic Rhinitis-NSAH Amevive Alefacept Biotech Amitiza Lubiprostone Laxative Antihemophilic Factor VIII & Antihemophilic Factor VIII Biotech Aranesp * Darbepoetin alfa Biotech Arava Leflunomide HIV Atriplia Avonex Benefix & other brands ; ? Betaseron Botox Caverject Celebrex Cellcept Chantix Claritin-D 12 hr Clarinex Reditab ; , Clarinex-D Coagulation factor IX ? Copaxone Copegus Ddavp Edex Eligard Enbrel Epogen * Exubera Feiba Forteo Gammar-P & other brands ; # Genotropin Gleevec Humate Humatrope Humira Hyalgen Immune Globulin# Increlex Infergen Intron-A * Iplex Iressa Kineret Lamisil Leukine * Lotronex Lucentis Lupron Macujen Muse Myobloc Nebupent Neulasta * Neupogen * Nexium * Nicoderm CQ Nicorette Nicotrol Nicotrol NS Nicotrol Inhaler Norditropin Novoseven Nutropin AQ ; Octagam Orencia Orthovisc Panglobulin Pegasys Peg-Intron Prevacid * Prevacid NapraPAC Prilosec 10 MG & 40 Prograf Protonix * Procrit * Efavirenz emtricitabine tenofovir Interferon, Beta-1a Coagulation factor IX Interferon, Beta-1b Botulinum Toxin Type A Alprostadil Celecoxib Mycopnenolate mofetil Varenicline Loratadine PSE Desloratadine Coagulation factor IX Glatiramer Acetate Ribavirin Desmopressin Alprostadil Leuprolide Etanercept Epoetin alfa Insulin, Regular Human Anti-inhibitor coajwant complex Teriparatide Immune Globulin Growth Hormone Imatinib Mesylate Growth Hormone Adalimumab Hyaluronate Na Immune Globulin Mecasermin Interferon Alfacon-1 Interferon alpha-2b Mecasermin Rinfabate Gefitinib Anakinra Terbinafine Sargramostim Gm-CSF ; Alosetron Ranibizumab Leuprolide Pegaptanib sodium Alprostadil Botulinum Toxin Type B Pentamidine Pegfilgrastim Filgrastim G-CSF ; Esomeprazole Nicotine Patch Nicotine Gum Nicotine Patch Nicotine NS Nicotine Inhaler Growth Hormone Factor VIIA, recombinant Growth Hormone Immune Globulin Abatacept Hyaluronate Na Immune Globulin Peginterferon Alfa-2B Peginterferon Alfa-2B Lansoprazole Lansoprazole Naproxen Omeprazole Tacrolimus Pantoprazole Epoetin alfa M.S. Biotech Biotech Biotech Biotech Impotence Cox II Anti-Rejection Smoking Allergic Rhinitis-NSAH Allergic Rhinitis-NSAH Biotech Biotech M.S. Hepatitis C Impotence Hormone Biotech Biotech Diabetes Osteoporosis Biotech Biotech Biotech Biotech Anti-Hemophilia Biotech Biotech Osteo Tx Biotech Biotech Biotech Biotech Biotech Biotech Biotech Antifungal Biotech Irritable Bowel Syndrome Macular Degeneration Hormone Macular Degeneration Impotence Biotech Antimicrobials Biotech Biotech PPI Smoking Smoking Smoking Smoking Smoking Biotech Anti-Hemophilia Biotech Biotech Arthritis Osteo Tx Biotech Biotech PPI PPI NSAID PPI Anti-Rejection PPI Biotech COVERED SERVICES UNDER PHARMACY BENEFIT Cont. ; Brand Name Generic Name Class Indication Regranex Becaplermin Biotech Remicade Infliximab Biotech Restasis Cyclosporine opthalmic Inc. Tear Production Retin-A for age 25 ; Tretinoid Acne Tx Ribasphere Ribavirin Hepatitis C Roferon -A * Interferon Alfa-2a Biotech Saizen Growth Hormone Biotech Serostim Growth Hormone Biotech Somavert * Pegvisomant Biotech Sporanox Stimate Supartz Sutent Synagis Synvisc Tasigna Tekturna Temodar Vfend Valcyte Visudyne Itraconazole Desmopressin Hyaluronate Na Sunitinib Palivizumab Hyaluronate Na Nilotinb monohydrate Aliskiren Temozolomide Vorconazole Valganciclovir Verteporfin Antifungal Hemophilia Factor Osteo Tx Oncology Biotech Osteo Tx Oncology Hypertension Biotech Antifungal Azole Antifungal Macular Degeneration and pemoline.
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The place is a functioning mobile headquarters now. Adler on the short wave and tacking up a map, Bobby Lee still in his corner, Red and Sally sitting across from one another at the "kitchen table". In the rear section of the Airstream Red's chair and a mini office for the Chief have been put together. ADLER Got a spot on 'em. A store right outside of Benhur. About 20 miles from here. Adler sets down the mike, sticks a tack on the map and stands back. RED All right. Push the roadblock on 288 north by 50 miles. Kaiser calls in the instructions. NOTE: Kaiser's radio transmissions are not scripted but go on a lot of the time we're in the Airstream. In addition, his and Adler's directions and missives to Bradley in the truck are not all scripted. ; CONTINUED.
Pegfilgrastim comes as an injection that is given once per chemotherapy cycle and penicillamine.
Patients, it appears unlikely that they had been tially lower risk of developing this complication.8.
Clinical remission is the treatment goal Starting DMARDs early improves clinical remission Figure 2 ; .24 Patients at risk of persistent and or erosive arthritis should be started on DMARDs as early as possible Box 2 ; .2, 5 and pennyroyal.
The concentration of pegfilgrastim decreases rapidly at the onset of neutrophil recovery following myelosuppressive chemotherapy.
The latency of minimal seizures Table 2 ; was systematically changed in two age groups only. Eighteenday-old rats exhibited a markedly delayed onset of these seizures in all cases, while 25-day-old animals after all doses at the four and six hour intervals. Only the 1200 mg kg dose led to a significant increase of latency 24 hours after vigabatrin; changes after the other doses and pentamidine.
Note: advice to quit should be noted in the patient's medical record and pegfilgrastim.
The molecular characteristics of pegfilgrastim result in a longer terminal half-life, making once-per-chemotherapy-cycle administration possible and pentasa
On the indicated day of culture, the medium was discarded for UCP1 mRNA determination 4 h after the addition of norepinephrine ; , the cells were dissolved in 1 ml Ultraspec Biotecx, Houston, TX ; solution, and the manufacturer's procedure for RNA isolation was followed. The final pellet was suspended in 75 l EDTA and the RNA extracted at 70 C for 5 min and thereafter vortexed. The RNA concentration was measured and absence of protein contamination was checked on a Beckman Coulter, Inc. DU 50 spectrophotometer with readings at 260 nm and 280 nm. The ratio of 260 280 nm was routinely higher than 1.7. The RNA solution was lyophilized in a SpeedVac. The RNA was then dissolved in 18 l RNA cocktail consisting of 50% vol vol ; formamide, 5 mm MOPS and 9% vol vol ; formaldehyde, and 2 l of loading buffer consisting of 50% wt vol ; glycerol and 0.1 mg ml bromophenol blue. The solution was incubated for 8 min at 70 C and then chilled on ice. The samples were loaded on a gel 1.25% agarose, 10 mm MOPS, 6.2% vol vol ; formaldehyde and 20 l 1 mg ml ethidium bromide ; . The gel was run in 20 mm MOPS-buffer for 23 h at cm. After electrophoresis, it was verified under UV-light from the intensity of the 18S-28S rRNA bands that all samples were equally loaded and that no degradation was observable. The RNA was blotted overnight from the gel to a Hybond-N membrane Amersham Pharmacia Biotech ; in 20 SSC. Three sheets of Whatman 3MM Kebo Lab., Spanga, Sweden ; soaked in 20 SSC were placed on top of the Hybond-N membrane. The gel and the Hybond-N membrane were examined under UV light. The RNA was cross-linked to the Hybond-N membrane [UV Stratalinker 1800 Stratagene, La Jolla, CA ; ] with the auto cross-link program ; . The Hybond-N membrane was prehybridized with 10 ml of solution containing 5 SSC, 5 Denhardt's solution, 0.5% SDS, 50 mm sodium phosphate, 50% formamide and 100.
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10 Kwak LW, Halpern J, Olshen RA et al. Prognostic significance of actual dose intensity in diffuse large-cell lymphoma: Results of a tree-structured survival analysis. J Clin Oncol 1990; 8: 963977. Lepage E, Gisselbrecht C, Haioun C et al. Prognostic significance of received relative dose intensity in non-Hodgkin's lymphoma patients: Application to LNH-87 protocol. Ann Oncol 1993; 4: 651 Bonadonna G, Moliterni A, Zambetti M et al. 30 years' follow up of randomised studies of adjuvant CMF in operable breast cancer: Cohort study. BMJ 2005; 330: 217222. Bosserman LD, Henderson IC. Cancer in America, 2004. Community Oncol 2004; 1: 30 Schwartzberg LS. Why we created this new journal. Community Oncol 2004; 1: 1113. Ozer H, Ding B, Dreiling L. The impact of first and subsequent cycle pegfilgrastim on neutropenic events in patients receiving myelosuppressive chemotherapy in community practice: Interim results of the prospective FIRST study. Community Oncol 2006; 3: 259 Crawford J, Wolff DA, Culakova E et al. First cycle risk of severe and febrile neutropenia in cancer patients receiving systemic chemotherapy: Results from a prospective nationwide study. Presented at the 46th Annual Meeting of the American Society of Hematology, San Diego, CA, December 4 7, 2004 and pentobarbital.
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