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Date Approved 29 July 2004 03 August 2004 11 August 2004 26 Oct. 2004 26 Oct. 2004 10 Nov. 2004 18 Nov. 2004 19 Nov. 2004 23 Nov. 2004 15 Dec. 2004 16 Dec. 2004 17 Dec. 2004 22 Dec. 2004 28 Dec. 2004 28 Dec. 2004 29 Dec. 2004 30 Dec. 2004 16 March 2005 16 March 2005 29 March 2005 28 April 2005 15 June 2005 16 June 2005 22 June 2005 22 July 2005 19 August 2005 30 August 2005 28 Oct. 2005 02 Nov. 2005 Proprietary Name Campral Cymbalta Pentetate Fosrenol Amphadase Omacor Tarceva VESIcare Multihance Lunesta Vision Blue Macugen Enablex Prialt Clolar Vent avis Lyrica Symlin Mycamine Baraclude Byetta Tygacil Levemir Aptivus Rozerem Nevanac Increlex Arranon Exjade INN FDA Established Name acamprosate duloxetine hydrochloride pentetate Lanthanum carbonate hyaluronidase Omega-3-acid ethyl esters erlotinib hydrochloride solifenacin succinate gadobenate dimeglumine eszopiclone Trypan blue pegaptanib sodium darifenacin hydrobromide ziconotide clofarabine iloprost pregabalin pramlintide acetate micafugin sodium entecavir exenatide tigecycline insulin detemir tipranavir ramelteon nepafenac mecasermin rDNA origin ; nelarabine deferasirox Serious Adverse Reactions Suicidal ideation or attempt Hypertension Wheezing Dialysis graft occlusion Angioedema none compared to corn oil ; infection Colonic intestinal obstruction none found ; Depression Staining certain intraocular lenses Endophthalmitis Acute urinary retention Syncope Febrile neutropenia Hypotension Accidental injury Hypoglycaemia Thrombophlebitis None described compared to lamivudine Hypoglycaemia Septic shock Lipodystrophy Bronchitis Somnolence Increased bleeding of ocular tissues Hypoglycaemia Blood dyscrasia Increased blood creatinine Nausea N Y Y Vomiting N Y N.
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The experiment was carried out in Galicia NW Spain ; . Twelve treatments were established in the spring of 1995 following a randomised block design with three replicas and they consisted of two densities 833 and 2500 trees ha ; , three types of fertilisation no fertilisation, milk sewage sludge fertilisation 154 m3 ha, meaning 160 kg total-N ha-1 ; , mineral fertilisation every year: 500 kg ha 8: 24: 16 compound + 40 kg after second cut ; and two types of sowing grass Dactylis glomerata and Lolium perenne ; Rigueiro et al. 2000 ; . Milk sewage sludge fertilisation was only applied on establishment and in this treatment, after the fourth year, mineral fertilisation was applied every year. Every experimental unit consisted of 25 trees distributed in a square of 5 x trees, which meant an area of 64 and 192 m2 for low and high density, respectively. Trees were planted in winter 1999 and yearly measured height and diameter ; . Tree pruning took place in the autumn of 2000. Pasture production estimated by harvesting the whole area limited by four inner trees ; , tree growth estimated by measuring the diameter caliper ; and the height of the 9 inner trees in each plot ; , botanical composition 100 grams of sward separated by hand ; , soil pH water 1: 2.5 and ClK ; at a depth of 25 cm were determined. ANOVA was used for statistical analyses, and means were separated by the Duncan test method.
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8: 39AM FG.00004 Nonlinear global modes in miscible coreannular flows , BALAKRISHNAN SELVAM, UCSB, LAURENT TALON, Universites P. et M. Curie, ECKART MEIBURG, UCSB -- We perform linear stability analyses and nonlinear simulations of variable viscosity, miscible coreannular flows in cylindrical tubes. For high viscosity ratios, these flows are found to be absolutely unstable, and they exhibit intrinsic oscillations different from the forcing frequency. These self-sustained oscillations give rise to nonlinear global modes. In the supercritical regime, with the core radius being the critical parameter, the nonlinear global mode frequencies match the linear absolute frequencies. This is in accordance with theory when the absolute frequencies are evaluated for the parameters at the inlet. We compare our simulations with recent experiments and observe excellent agreements. 8: 52AM FG.00005 Stability Results on Multi-Layer Hele-Shaw Flows , PRABIR DARIPA, Texas A&M University -- The upper bound results on the growth rates in unstable multi-layer Hele-Shaw flows will be derived. The cases treated are constant viscosity layers and variable viscosity layers. The upper bound provides a way to assess cumulative effects of many layers and many interfaces on the growth rates of unstable waves. As an application of the bound, we obtain some sufficient conditions for suppressing instability of two-layer flows by introducing arbitrary number of constant viscosity fluid layers in between. This sufficient condition has very practical relevance because it narrows the choice of internal layer fluids based on surface tensions of all interfaces and viscosities of fluids. Importance of this condition which has been hitherto unknown is also discussed. Other consequences of these upper bounds and sufficient conditions are discussed. The case of internal fluid layers having unstable viscous profiles is also treated for three-layer and four-layer flows only. Implications of these stability results for these various multi-layer flows are discussed and compared from practical standpoint. 9: 05AM FG.00006 Influence of Interface Thickness on the Digitation of Miscible Fluids , GEORGES GAUTHIER, FAST UPS Paris11, ALBAN AUBERTIN, JEROME MARTIN, LAURENT TALON, FAST CNRS, DOMINIQUE SALIN, FAST UPMC Paris6 -- The influence of the interface thickness on miscible viscous fingering instability, has been studied in a Hele-Shaw cell. Using a pair of fluids with a small density contrast, we took advantage of parabolic flights sequences, to either restore a flat thick initial interface under MACROGRAVITY or get rid of buoyancy effects during the unstable displacement under MICROGRAVITY conditions. The experiments demonstrate that the initial thickness of the interface does not affect significantly the instability mechanism, but only postpones the appearance of the digitation. More precisely, the initial thickness delays the formation of a shock in the base state concentration profile, but the shock formation still triggers the instability. 9: 18AM FG.00007 Convective and Absolute Instability of Two Miscible Fluids Core-Annular Flow , MARGUERITE D'OLCE, FAST UPMC Paris6, JEROME MARTIN, FAST CNRS, NICOLE RAKOTOMALALA, FAST UPMC Paris6, LAURENT.
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Of aggressive adjuvant chemotherapy has substantially improved survival of patients with musculoskeletat sarcomas 1-3 ; . Administration of chemotherapy before surgical resection or irradiation neoadjuvant therapy ; permits immediate delivery of maximum doses of cytotoxic drugs to the primary tumor and any occult or overt metastases. Accurate determination of tumor response during this initial phase of treatment is vital in assessing the effectiveness of the therapy used, planning further treatment, and predicting prognosis 4-6 ; . Because clinical methods of measuring chemotherapeutic response of musculosketetal tumors are someSE.
To describe CsA pharmacokinetics in the population of interest, i.e. recipients with an abnormal absorption profile. The differences in CsA pharmacokinetics between KTA and SPKT recipients were adequately detected by the compartment model and by one of the previously described LSMs [6]. The performance of the other LSM was significantly worse [7], indicating that caution should be taken when monitoring CsA in various patient groups with defined sampling time-points. This is illustrated especially by the lack of correlation between C2h and AUC04h or AUC012h in SPKT recipients as compared with the patients without diabetes mellitus, who received a kidney transplant. In Figure 6, two clinical examples are given illustrating the above-mentioned issues and how the model deals with them. Although the drug is metabolized to at least 25 metabolites, blood concentrations of CsA after oral and primaquine.
The changes experimentally induced at the giant loop loci of T. c. carnifex are probably comparable to the changes which Beermann3 induced in puffs and Balbiani rings by manipulation of temperature. When Chironomus larvae were kept at temperatures lower than io c C for a few hours and then transferred to water at 200 C for 1 h, droplets formed at the sites where puffs are normally present. After 2 to 8 200 C Beermann found that the droplets had disappeared. Changes induced at the giant loop and other loci in T. c. carnifex do not compare with the changes induced at the I-18-C and IV-2-B loci on the salivary gland chromosomes of Chironomus teutons by treatment of the larvae with ecdysone11. Ecdysone, unlike gonadotrophin, has a highly specific effect. I have been able to record changes at only a few loci in T. c. carnifex because those loci are, under normal circumstances, the most conspicuous and therefore the ones most likely to change perceptibly. A reasonable explanation of the physiologically determined morphological variability of lampbrush chromosomes is the proposal of Callan and Lloyd8 that products of lateral loop synthesis accumulate at their site of formation only if they are being formed more rapidly than they are passing into or being transformed into nuclear sap. An artificially supplied stimulus such as an injection of gonadotrophin might be expected, by accelerating cellular metabolism, to increase the demand for the primary products of gene-controlled synthesis. For a time, the products of lateral loop synthesis might be used up more rapidly than they are inherently capable of being formed: thus by loss of matrix the loops themselves would become smaller. One would anticipate the effects of hypophysectomy to be opposite in all respects. Physiologically determined morphological variability of chromosomes is common enough if we include under this heading the variability of nucleoli in somatic cells. A true nucleolus is attached to a specific locus on a chromosome25' 29. The nucleolar substance is a gene product in the sense that it is synthesized at a specific locus and has certain peculiar properties. Nucleolar size is said to vary according to the rate at which protein is being synthesized in the cytoplasm9' I0 l8 ' The lampbrush chromosome loci in Ambystoma tigrinum and T. viridescens, which are thought to be homologous to the nucleolar organizer loci of somatic cells in these species20, would be worth studying to see whether they become more or less conspicuous after gonadotrophin treatment. The results of my own studies on T. c. carnifex suggest that, where the giant loops are concerned, large size does not necessarily indicate intense metabolic activity, either on the chromosomes or elsewhere in the cell. The free granules of newt oocyte nuclei are optically dense, they are always round, and they vary in size from the limits of visibility with the light microscope to 3 or diameter. They contain cytochemically demonstrable RNA, they are dissolved by trypsin and pan-protease at pH 8 and by pepsin at pH 2, but they are not completely dissolved by ribonuclease unpublished personal observations ; . The granules which characterize the giant granular loops of chromosome XII in T. c. cristatus have similar properties. The unqualified.
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Date: Patient Name: Patient Address: Patient Date of Birth: SS#: To Whom It May Concern: This letter serves as a request and clinical justification for the above referenced patient to begin treatment with PRIALT ziconotide intrathecal infusion ; . The patient exhibits the following signs, symptoms, and or conditions and would benefit clinically by receiving PRIALT. [Provide detailed reasons why PRIALT was prescribed including information on patient's condition and previous medications.] I believe that the distress and discomfort experienced by this patient requires immediate attention. Patient profile: Diagnosis please specify ; : Current pain medications: Patient was previously treated with: Reason for discontinuation or change in therapy: Prescribed PRIALT use including compounding and or titration schedule ; : I have enclosed copies of pertinent notes, laboratory and other test results for your reference. I have also enclosed information on PRIALT and published data regarding clinical utility. I certify that this is information is correct. If you have any questions about this request, please feel free to contact me. I would be more than willing to discuss this specific case with you. Sincerely, Insurance Plan.
Ic~nin~c~ilrenlent tlic expt\r~mrnt mean da~lc oi i ~ tt.1npc.1 vt ilurci 12~t.1t, as Is\ a i 10 C, well I elo\ tlic, I ~ t ~ lternpc3r'it~~ie 25 kg plg5 Close, l foi l L ; \' ttc3c of the 1011 'irnb~rnt tc9mperaturc t ; ~olildh, i\ c to sonie clrgrtc L3ct.n rcduceci by tlie stra\ Ix~clding i~idtlic pigs huddling together riti~ol~gIi i i still lil\c, Jy to Iia\ e incrcased food intake 1t i to pigs r'iistd in 1 thermoneutr'11 ' i.111il-onmcnl. Ihc. cttect of this increcist~in food 111t, i1ten protoin lccretion r itcs\VOLIICI dcpertd upon o \vlietlic~r c, lic, rg!. int'ikc., or Iysine, viras , I limiting ionitr, ~illt protein c~c-cretioil. for Campbell 11 ill. 1983 ; . ~ l c~eight tli, it r, lnge of 20 to gilts gi\ e ~ i toocl ; I near i7~lliliiiriiir i1it; tkes did not show , ill\, i ~ ~ c ~in lprot ~in'lccretion rates with further ~ st~ incrt~~isc~s 111 intake, altlio~~gli entire males protein in acc.rc.tion rCiteswere linearly related to energy intake L I P 111 Iil~ilriiirle\rels. At the higher weights the gr'iplis i l l Fig~~l-esi~ggcstthat food intake was 1 3 ' limiting factor for protein accretion for the gilts in genotype 3 rcl, ltive to genotype I , which would ~grct \sit11 Cclmpbell cpt171. 1983 ; who showed that for pigs grocvn o ~ under a restricted feeding regime ~ t from 45 to 90 protei~i accretion was infl~~cnced by Ie\.rl of food int'lkt. In this stud!, the protein accretion curve [d Pr ; df] was described as a function of the rate of increase in daily food intake dF df ; , the decline in food efficitmcy dW dl ; and the rate of protein deposition rclati\, e to live weight d lJr. ; dW ; . The rate of protein accretion relative to live weight [d Pr ; dW] nrcisalmost 'I constant in this study, and therefore the protein '~ccretioncurbe was largely a function of rate of incrcasc in food intake and the decline in food cfticicncy, the product of which is growth rate Parks, 1982 ; . The form of the function used to describe grow'tli therefore becomes critical in clcterrninii~g the properties of the protein accretion curve. In tlie study by Whittelnore rJf ill. 1988 ; the tlse ot tlie Gompertz equation to describe live weight , is 3 f~mction age has the limitation that the point ' of of inflexion is fixed at 0.368 of mature weight. It then tollows thdt the stage of maturity at which tlie m, ixirnum growth rate and maximum protein lccretionoccurs is c~lso fixed. On the other hand, the I'arks model has no such restriction o n the age, or st, lge of maturity, at which the point of inflexion occurs. li, i ther the maxim~un rate of protein accretion is clt tt.rrnincdby the product of the food intake and iood efficiency functions. Although the Parks model h, ~s less restrictioi~s than the Gompertz model, both ha\ lirnit, ltions in that thcy arc still simplistic cmpil-ic, ll ~lescriptions of a complex biological ivstem. There are few cldtn 011 m, lture weights of pigs from ciittc~rc~nt gc3~iotvpes being gi\, en nd libitlrirr access to a and probenecid.
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Elcome to the Autumn issue of The Endocrinologist. We hope that you have all had a restful summer and aren't too horrified by the thought of being back to work. What's that I hear, it's like you've never been away! Well, we have much to stimulate your flaccid neurons in this issue. This year's publication of the human genome sequence and the realisation that it comprises upwards of 100 000 genes begs the question of what do all these genes do? The discipline of functional genomics aims to answer this and one strategy employed is gene expression profiling using DNA microarray technology. On page 8 Claire Johnson describes the theory, practice and potential of this exciting new technique, demonstrating how it will impact on our understanding of physiology and disease. As scientists and practising endocrinologists it is very easy to overlook the patient experience. On page 9 Patsy Perrin provides us with a very moving insight into how she lives with acromegaly. Read on to John Lazarus' page 11 revelations of the alternative life of thyroid hormones.
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ELAN REPORTS FOURTH QUARTER AND FULL-YEAR 2004 FINANCIAL RESULTS Dublin, Ireland, February 8, 2005 - Elan Corporation, plc today announced its fourth quarter and full-year 2004 financial results and provided an update on its outlook for 2005. Commenting on Elan's business, Kelly Martin, Elan's president and chief executive officer, said, "2004 was an extraordinary year for Elan, with two Elan innovations, Tysabri for multiple sclerosis and Prialt for severe chronic pain, approved in the US, with both therapies advancing in the regulatory process in Europe. For 2005, we look forward to continued growth across the Tysabri franchise, working with our collaborator Biogen Idec; continued clinical progress in the Alzheimer's immunotherapy programme in collaboration with Wyeth; ongoing advancements in our strategic pipeline; and disciplined investment aligned to our core therapeutic areas of autoimmune diseases and neurodegenerative diseases. Our company and our people remain steadfastly focused on our commitment to discover and deliver novel therapeutic approaches for patients with significant unmet medical needs and to bring sustainable growth and value creation to our shareholders." Commenting on Elan's fourth quarter and year-end 2004 financial results, Shane Cooke, executive vice president and chief financial officer, said, "2004 has proven to be a transitional year for Elan; we reduced losses by 33% to ##TEXT##.96 per share; experienced double digit growth in revenues from our remaining business; completed the repositioning of our business and balance sheet with continued disciplined and focused investment in our core therapeutic areas; expanded our organisation in targeted areas by recruitment of key talent to execute the successful launch of Tysabri and Prialt; and we significantly strengthened our financial position completing a billion plus bond offering. While it is early days, the initial take-up since launch of Tysabri is exceeding all our expectations and we remain optimistic that we will return to profitability by the end of 2006 and procaine
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Dear Woodland Stakeholders, This year, our district embarked on a new mission: the development of a five-year strategic plan that will shape the future of Woodland. The process of developing a strategic plan began in the fall of 2006 and included the input of 63 parents, students, staff and community members. The strategic plan includes the mission, vision, beliefs, core values, and defined initiatives for the district. Whether it's a student in a classroom learning a new math problem, a custodian trying to resolve an issue in one of the schools or a nurse determining what is best for a child, we are all tied toward helping one another in the learning process. We look forward to sharing the detailed elements of our strategic plan in early spring. Last year, we introduced our 2005-2006 district goals to the community in the annual report. It is imperative that we report back to our community regarding how we, as a district, accomplished the goals. The four goals were: student learning, fiscal responsibility, internal and external community. Page four lists a review of these goals. The financial overview of the district budget can be found on page 11. We believe in the importance of being open and honest with our budget information so that parents and community members can have a clear understanding of our financial picture. This school year, we are thrilled to announce the establishment of our Woodland Educational Foundation. The mission of the foundation is: to creatively generate and distribute resources with which to enrich and enhance the opportunities and educational experiences of Woodland Community Consolidated School District 50 students. More information regarding the Educational Foundation is on page eight. We are proud of this district: our students and our staff. Educational excellence is not accomplished overnight. What leads us down this path is a unique combination of dedication, determination and true commitment. It is something that fills our hallways, classrooms, offices and the community. As your Superintendent of Superintendent of Schools Dr. Joy Swoboda Schools and Board of Education President, we bottom right ; and Board President Dr. Carla Little top right ; pose with the students of Marion are honored to serve this community and look Beram's art class. forward to another successful and rewarding school year in Woodland Community Consolidated School District 50 and procrit.
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