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Undergraduate Student Assistant A two-time WAC Defensive Specialist of the Year for BYU, Petrilli continues to use her experience, knowledge and work ethic as an undergraduate student assistant in 1999. Petrilli came to BYU after a a stellar career at Granada High School in Livermore, Calif., where she was named team MVP. She played in 450 games for BYU over her career and ended with 915 digs, sixth on BYU's alltime list. She is currently working to complete a degree in psychology.
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3 9. Two molecular agents are now FDA approved Avastin and Erbitux ; . How are they to be included in FU + LV? How are they used with FOLFOX, FOLFIRI, etc.? 10. In addition, if the above nine questions relate to metastatic colorectal cancer, then how are they to be answered in the adjuvant setting? Despite the sarcastic acronymic humor, we are pleased to have a few new additions of chemotherapy and molecular agents for colorectal cancer. A great deal of work has been invested into medical oncologic approaches over the past 40 years. Even President Reagan's bout with Dukes' B disease did not propel the advances in research. Beneficial results are only recently evolving, some of which are seen in adjuvant trials as well. The years of arguments over the scheduling of FU and at the dosing of LV have been frustrating, especially since response rates, time to progression, and overall survival so often times are nearly the same. When irinotecan became available, all treatment parameters improved but at the price of toxicity. Toxicity is an important factor for the efficacy scale of colorectal cancer because beneficial treatment results are not marked. In our community, irinotecan combinations are used by oncologists, but without great enthusiasm. Oxaliplatin has become a more popular drug. Toxicity is more manageable except for the distinctiveness of cold sensitivity; patients are to avoid the use of cold caps, refrain from having ice cubes in the mouth, and maintain a distance from refrigerators and freezers. Although FOLFOX is becoming the preferred treatment regimen, which one of the 7 varieties does one use? The two new molecular agents Avastin and Erbitux ; that are approved are for use in metastatic disease. Their use in adjuvant therapy is under investigation. The toxicity spectrum of molecular agents is generally mild although there is an increase in reports of venous thromboembolic events. Unfortunately, these drugs do not have significant effectiveness when used alone and they should be combined with chemotherapy. We anxiously await new studies to judge the therapeutic effectiveness when molecular agents are added. CTSU and pharmaceutical protocols are employing them with FOLFOX and FOLFIRI both in metastatic disease as well as in the adjuvant setting. Obviously the number of our acronyms for the treatment of colorectal cancer will expand. It shall take several years before the correct acronym s ; finds its way into treatment guidelines. Until then, be wary of the articles that are appearing in clinical journals. The editorial in JCO was trying to clarify the use of FU by referring to a manuscript that appeared in the same journal issue. However, immediately following the article to which he was referring[2] was an article that had still another oxaliplatin + FU + combination from Norway Nordic FLOX ; [3]. In this paper, the infusion schedule was markedly different from "standard infusions, " only a few patients were investigated, and there was no control group. This only adds more confusion with another unsubstantiated recipe to the confusion that already existed because of so many cocktails have been made up of the same 4 drugs and ergotamine.
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Greetings to all Young Bugs in Victoria, I'm Philip Button. Presently I'm in the process of taking over from Wendy McDonald as student rep on the Victorian Branch Committee. Firstly, some brief background info about myself I'm a PhD student in the School of Agriculture and Food Systems at The University of Melbourne and based at Food Science Australia, Werribee. For my project, I'm looking at spoilage of dairy products caused by bacterial enzymes. I passionate and enthusiastic about microbiology and student involvement in professional associations, and so I very pleased to be on the Victorian Branch Committee. One piece of advice to all students take full advantage of all the fantastic things on offer to you by the ASM like discounted membership, conference registration and Microbiology Australia, attend the many wonderful events on offer, make the most of the opportunity to meet some great fellow microbiologists, as well as lots more. We at the ASM are here to make your careers more fulfilling even if, as a student, you are in the very early years of your career ; , so visit our branch website or contact me to find out the ways to become active in your professional association, the ASM! Philip Button.
With Bao, Xiliang ; Hyperideal polyhedra in hyperbolic 3-space. English and French summaries ; Bull. Soc. Math. France 130 2002 ; , no. 3, 457491. Raquel Daz ; i 2003k: 52007 52A55 ; garibay Bonales, Fernando see Garibay Bonales, Fernando Bonaly, A. with Bounias, Michel ; Topological foundations of self-conscious perception functions in the mathematical space of the brain. English summary ; Ultra Sci. Phys. Sci. 14 2002 ; , no. 2, 218229. Yehuda Rav ; 2003f: 92007 92B20 ; Bonami, Aline with B koll , David; Garrigos, Gustavo ; Littlewood-Paley decompositions e e related to symmetric cones. English summary ; IMHOTEP J. Afr. Math. Pures Appl. 3 2000 ; , no. 1, 1141. Charles N. Moore ; 2003d: 42027 42B25 ; with Hilhorst, Danielle; Logak, E.; Mimura, Masayasu ; Singular limit of a chemotaxis-growth model. English summary ; Adv. Differential Equations 6 2001 ; , no. 10, 11731218. Summary ; 2003d: 35141 35K57 ; with Peloso, Marco M.; Symesak, Fr d ric ; On Hankel operators on Hardy and e e Bergman spaces and related questions. English summary ; Actes des Rencontres d'Analyse Complexe Poitiers-Futuroscope, 1999 ; , 131153, Atlantique, Poitiers, 2002. Miroslav Engli ; 2003k: 47037 47B35 ; s with Buraczewski, Dariusz; Damek, Ewa; Hulanicki, Andrzej; Penney, Richard; Trojan, Bartosz ; Hua system and pluriharmonicity for symmetric irreducible Siegel domains of type II. English summary ; J. Funct. Anal. 188 2002 ; , no. 1, 3874. A. Kor nyi ; a 2003c: 32023 32M15 Bonanno, A. with Reuter, Martin ; Cosmology of the Planck era from a renormalization group for quantum gravity. English summary ; Phys. Rev. D 3 ; 65 2002 ; , no. 4, 043508, 20 pp. Summary ; 2003c: 83148 83F05 ; Bonanno, Claudio with Menconi, Giulia ; Computational information for the logistic map at the chaos threshold. English summary ; Discrete Contin. Dyn. Syst. Ser. B 2 2002 ; , no. 3, 415431. Summary ; 2003c: 37047 37E05 ; with Galatolo, Stefano; Menconi, Giulia ; Information of sequences and applications. English summary ; Non extensive thermodynamics and physical applications Villasimius, 2001 ; . Phys. A 305 2002 ; , no. 1-2, 196199. Summary ; 2003i: 94026 94A17 and erlotinib.
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Terms of frequency of occurrence were European pilchards 49.5% ; and European anchovies 39.8% ; . The possible reasons behind the precipitous decrease of common dolphin numbers in the area of Kalamos were discussed by Bearzi et al. 2005 ; , who did not regard direct killings, bycatch and contamination by xenobiotics as primary causes of the observed decline. Changes in oceanographic parameters can have large-scale impacts on the distribution and or abundance of high-order predators, primarily by influencing the availability of their prey. In the study area, however, SSTs did not show obvious annual trends and were not correlated to the observed encounter rates. The potential effect of monthly SST fluctuations could not be considered due to small sample sizes. However, such short-term fluctuations would not be especially good candidates for explaining the regular, continuous decline of common dolphins throughout the study period. Whether the observed trends were simply a consequence of migratory behaviour or long-range movements is not known, and this hypothesis certainly deserves further investigation, also considering the relatively small size of our study area. To date, surveys conducted outside the study area between 1997 and 2004 provided no evidence to suggest that the core of the common dolphin community has shifted elsewhere Bearzi et al., 2005 ; . The patterns observed in the eastern Ionian Sea are consistent with the hypothesis of a decreased availability of key prey in the study area, making this coastal habitat less capable of sustaining large predators. Although prey overlap between high-order predators and fisheries does not necessarily imply direct competition Briand, 2004 ; , it is reasonable to assume that such competition might occur when key prey for high-order predators is scarce and subjected to heavy exploitation Trites et al., 1997 ; . Excessive fishing pressure is a growing concern, worldwide e.g., Jackson et al., 2001; Pitcher, 2001; Pauly et al., 2002 ; and is having profound direct and indirect impacts on Mediterranean ecosystems Sala, 2004 ; . Although in the Mediterranean there is an acute lack of historical data Briand, 2000, 2003 ; , it is acknowledged that unsustainable harvesting led to the decline of many fish stocks Caddy and Griffiths, 1990; De Walle et al., 1993; Stanners and Bourdeau, 1995; Caddy, 1997; Briand, 2000; FAO, 1997, 2000; Pauly and Palomares, 2000 ; . Many stocks are considered to be outside safe biological limits and some are in a critical state, largely because more fishing is allowed than is recommended by scientific advice EEA, 2003 ; . Overall, 60% of European fish catches would exceed safe limits, i.e., levels above which the biomass removed by fishing is no longer replaced by population growth EEA, 2004 ; . In the wider Mediterranean, dramatic ecological changes were highlighted inter alia by Caddy 1997 ; , who expressed concern about the stock status of northern bluefin tuna and swordfish, threatened by the apparently unrestrained growth of surface gillnet and longline fisheries, as reflected by progressive decreases in mean size and age at capture Stergiou et al., 2003 ; . In a review of the state of exploitation of Mediterranean fish stocks between 1950 and 1994, the FAO 1997 ; reported European pilchards to be Moderately exploited Fully exploited; European anchovies and swordfish were reported as Fully exploited Overfished; northern bluefin tuna and albacore as Depleted.
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3.2.2. Commercial cultivation For the commercial release of a genetically modified crop, permission at an EU level should be sought. The notifier is therefore required to supply details, among others, on the DNA insert, expression levels of transgenic proteins, composition of the transgenic plant, and safety of the transgene product, including data from field trials. Commercial releases are regulated by EU Directive 90 220, Part C, under which an application has to be submitted to a national authority and subsequently to the European Commission Figure 1 ; . A guidance document on dossier preparation has been issued by the Scientific Committee on Plants of the European Commission SCP, 1998 ; . EU Directive 2001 18, which will replace EU Directive 90 220 in the year 2002, has recently been adopted. The amendments include, among others, the requirement for post-marketing monitoring, the compulsory labelling of the genetically modified products, and the availability of detection methods for the genetically modified plant. In addition, genetically modified plants that are intended for production of medicinal products will be exempted from the risk assessment under EU Directive 90 220 EP, 2001a ; . 3.2.3. Import of genetically modified crops or crop products EU The import of viable genetically modified products requires the market approval under EU Directive 90 220, part C. If the imported product is to be used as food or food ingredient, additional permission for food use shall be sought under the EU Regulation 258 97 for Novel Foods. USA The import-, movement between States-, and the environmental release- of genetically modified plants and seeds come under the scrutiny of the Animal- and Plant- Health Inspection Service APHIS ; , which resorts under the U.S. Department of Agriculture USDA ; . Considered, among others, will be the GMO's potential to become a plant pest Vogt and Parish, 1999 ; . The import of genetically modified foods and feeds fall under the regulatory oversight of the Food and Drug Administration FDA and eszopiclone.
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Takeuchi et al showed positive correlations between metastatic PC and abnormal alkaline phosphatase and a similar correlation between Pd and Dpd and bone metastases. No such relationship was seen with osteocalcin. Patients with BPH or clinically localized PC had no elevation of Pd or Dpd. Alkaline phosphatase is normally elevated during adolescence during the period of rapid bone growth. Most scientists therefore regard alkaline phosphatase as a marker of osteoblastic activity. We now know that the PC cell makes various substances that stimulate the osteoblast, e.g. uPA, PTHrP, Endothelin-1, TGF . Therefore, it is not surprising to see bone changes that reflect this increase in osteoblastic activity. Examples are increased uptake on the bone scan and the appearance of dense sclerotic ; bone metastases. Elevations of alkaline phosphatase, in the setting of PC, are due to osteoblastic metastases stimulated by PC cell products and by bone-derived growth factors until proven otherwise and erbitux.
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HRS is the most advanced stage of the various pathophysiologic derangements that take place in patients with cirrhosis. The hallmark of HRS is intense renal vasoconstriction that starts at an early time point and progresses with worsening of the liver disease 7 ; . The underlying mechanisms that are involved in HRS are incompletely understood but may include both increased vasoconstrictor and decreased vasodilator factors acting on the renal circulation. Type 2 HRS is gradually progressive and arises in association with the progression of cirrhosis, whereas type 1 is an acute deterioration in kidney function associated with severe renal vasoconstriction and failure of compensatory mechanisms that are responsible for maintenance of renal perfusion 8 ; . Four interrelated pathways have been implicated in the pathophysiology of HRS. The possible impact of each one of these pathways on renal vasoconstriction and the development of HRS varies from one patient to the other. These pathways include: 1. Peripheral arterial vasodilation with hyperdynamic circulation and subsequent renal vasoconstriction; 2. Stimulation of the renal sympathetic nervous system SNS 3. Cardiac dysfunction contributing to the circulatory derangements and renal hypoperfusion; 4. Action of different cytokines and vasoactive mediators on the renal circulation and other vascular beds.
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[Mr. Brennan.] tification will be adopted for customers on offshore islands and other remote areas of the country. The changes represent a significant improvement in customer service by enabling all unemployed customers to have direct contact with their social welfare local or branch office, where they can be directed to the many educational and work supports available to the unemployed. To qualify for unemployment payment, a person must show that he or she is available for and genuinely seeking work. The Department of Social and Family Affairs normally expects unemployed customers to take up offers of employment within a reasonable distance of their residence and to travel there on a daily basis. A distance of 11 miles would not be considered excessive. In such circumstances it is not unreasonable to require a customer who is actively seeking work to travel to his social welfare local office for certification purposes once every 12 weeks. If customers have particular difficulties with the revised arrangements, officials in the local offices will be glad to consider them and to make whatever adjustments are considered appropriate. Community Development. 195. Mr. Stanton asked the Minister for Social and Family Affairs the number of changes that he announced to the cutbacks of 2004 on 1 December 2004 which require circulars to community welfare officers; if he will identify each change that requires a circular to community welfare officers; if and when he has issued these circulars; when each change comes into effect; and if he will make a statement on the matter. [2376 05] 196. Mr. Stanton asked the Minister for Social and Family Affairs the date on which each of the changes that he announced to the cutbacks of 2004 on 1 December 2004 come into effect; and if he will make a statement on the matter. [2377 05] 197. Mr. Stanton asked the Minister for Social and Family Affairs the number of persons affected by each of the changes that he announced to the cutbacks of 2004 on 1 December 2004; the cost to the State; and if he will make a statement on the matter. [2378 05] Minister for Social and Family Affairs Mr. Brennan ; : I propose to take Questions Nos. 195 to 197, inclusive, together. At the time of the recent budget, I announced my intention to make changes relating to the rent ` supplement and creche and diet supplements, which are provided for under the supplementary welfare allowance scheme, which is administered on my behalf by the community welfare staff of the health service executive. I have made two changes in the conditions for receipt of rent supplement. To ensure that bona and ergotamine.
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No one should have been surprised. Similar results in Phase II trials of panitumumab Malik, Abstract 3520, ASCO 2005 ; or Erbitux Lenz, Abstract 3536, ASCO 2005 ; monotherapy in refractory colorectal cancer had prepared the field to expect equivalent efficacy from the two products. But since many including DaVinci ; had thought the same would be true of Iressa gefitinib; AstraZeneca ; and Tarceva erlotinib; OSI Pharmaceuticals Genentech Roche ; , only to be proven spectacularly wrong when Iressa failed to increase survival in patients with recurrent non-small cell lung cancer the same setting where Tarceva had shown benefit ; , DaVinci remained open to the unexpected. But this time, it really is true: these two drugs are as different as Coke and Pepsi. The table below shows the high degree of concordance between the results of the pivotal trials in the measures that matter: response rate, freedom from progression, and survival and etidronate.
Chromosomal competency of embryos correlates with ovarian response after mild stimulation The distribution of the number of oocytes retrieved per patient was different following conventional and mild ovarian stimulation, with skewing of the curve following mild stimulation towards fewer oocytes Figure 3a and b ; . For each stimulation protocol, differences in the proportion of abnormal embryos based on one-cell diagnosis were correlated to ovarian response per patient Figure 3c and d ; . Within the mild group, a significant positive correlation Pearson correlation 0.4; P 0.006 ; was observed between the number of oocytes obtained and the proportion of abnormal embryos. In the conventional stimulation group, no correlation was observed Pearson correlation 20.08; P 0.679 ; . The distribution found after mild stimulation was significantly different from the one found after conventional stimulation P 0.016; test for interaction in ANOVA ; . Mild ovarian stimulation results in a reduced proportion of abnormal and mosaic embryos Table III summarizes outcome measures and clinical results per patient. Although more oocytes were obtained per patient following conventional ovarian stimulation 12.1 versus 8.2, P 0.001 ; , no differences were observed in fertilization rates or percentage of embryos biopsied and diagnosed between the groups. The proportion of embryos with normal morphology was higher after mild, when compared with conventional ovarian, stimulation 51 versus 35%; P 0.04 ; . On the basis of the first cell biopsied, the proportion of chromosomally abnormal embryos per patient was significantly decreased following mild stimulation Table III ; . The percentage of abnormal embryos relative to the number of embryos diagnosed was 45% following mild stimulation 40 patients ; compared with 63% following conventional stimulation 33 patients; P 0.02 ; . Mild stimulation resulted in significantly less oocytes and embryos, but there was no difference between the two study groups in the average number of chromosomally normal embryos 1.8 ; obtained per patient Figure 4 ; . By analysing the group of embryos in which two cells were available for diagnosis, insight into chromosomal mosaicism could be obtained Table III ; . In this group, the diagnosis could.
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